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ER strikes again: Proteostasis Dysfunction In ALS.
Maharjan N, Saxena S. Maharjan N, et al. EMBO J. 2016 Apr 15;35(8):798-800. doi: 10.15252/embj.201694117. Epub 2016 Mar 11. EMBO J. 2016. PMID: 26968985 Free PMC article.
It Takes Two to Tango: DPRs in ALS and SCA36.
Maharjan N, Saxena S. Maharjan N, et al. Neuron. 2020 Jul 22;107(2):202-204. doi: 10.1016/j.neuron.2020.06.025. Neuron. 2020. PMID: 32702342 Free article.
Emerging Perspectives on Dipeptide Repeat Proteins in C9ORF72 ALS/FTD.
Schmitz A, Pinheiro Marques J, Oertig I, Maharjan N, Saxena S. Schmitz A, et al. Among authors: maharjan n. Front Cell Neurosci. 2021 Feb 18;15:637548. doi: 10.3389/fncel.2021.637548. eCollection 2021. Front Cell Neurosci. 2021. PMID: 33679328 Free PMC article. Review.
PolyGA targets the ER stress-adaptive response by impairing GRP75 function at the MAM in C9ORF72-ALS/FTD.
Pilotto F, Schmitz A, Maharjan N, Diab R, Odriozola A, Tripathi P, Yamoah A, Scheidegger O, Oestmann A, Dennys CN, Sinha Ray S, Rodrigo R, Kolb S, Aronica E, Di Santo S, Widmer HR, Charlet-Berguerand N, Selvaraj BT, Chandran S, Meyer K, Zuber B, Goswami A, Weis J, Saxena S. Pilotto F, et al. Among authors: maharjan n. Acta Neuropathol. 2022 Nov;144(5):939-966. doi: 10.1007/s00401-022-02494-5. Epub 2022 Sep 19. Acta Neuropathol. 2022. PMID: 36121477 Free PMC article.
The process of Lewy body formation, rather than simply α-synuclein fibrillization, is one of the major drivers of neurodegeneration.
Mahul-Mellier AL, Burtscher J, Maharjan N, Weerens L, Croisier M, Kuttler F, Leleu M, Knott GW, Lashuel HA. Mahul-Mellier AL, et al. Among authors: maharjan n. Proc Natl Acad Sci U S A. 2020 Mar 3;117(9):4971-4982. doi: 10.1073/pnas.1913904117. Epub 2020 Feb 19. Proc Natl Acad Sci U S A. 2020. PMID: 32075919 Free PMC article.
90 results