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Page 1
Genomic dissection of 43 serum urate-associated loci provides multiple insights into molecular mechanisms of urate control.
Boocock J, Leask M, Okada Y; Asian Genetic Epidemiology Network (AGEN) Consortium; Matsuo H, Kawamura Y, Shi Y, Li C, Mount DB, Mandal AK, Wang W, Cadzow M, Gosling AL, Major TJ, Horsfield JA, Choi HK, Fadason T, O'Sullivan J, Stahl EA, Merriman TR. Boocock J, et al. Among authors: major tj. Hum Mol Genet. 2020 Apr 15;29(6):923-943. doi: 10.1093/hmg/ddaa013. Hum Mol Genet. 2020. PMID: 31985003
Dietary Sodium Modifies Serum Uric Acid Concentrations in Humans.
Todd AS, Walker RJ, MacGinley RJ, Kelly J, Merriman TR, Major TJ, Johnson RJ. Todd AS, et al. Among authors: major tj. Am J Hypertens. 2017 Nov 6;30(12):1196-1202. doi: 10.1093/ajh/hpx123. Am J Hypertens. 2017. PMID: 28985270 Free PMC article. Clinical Trial.
Discordant association of the CREBRF rs373863828 A allele with increased BMI and protection from type 2 diabetes in Māori and Pacific (Polynesian) people living in Aotearoa/New Zealand.
Krishnan M, Major TJ, Topless RK, Dewes O, Yu L, Thompson JMD, McCowan L, de Zoysa J, Stamp LK, Dalbeth N, Harré Hindmarsh J, Rapana N, Deka R, Eng WWH, Weeks DE, Minster RL, McGarvey ST, Viali S, Naseri T, Sefuiva Reupena M, Wilcox P, Grattan D, Shepherd PR, Shelling AN, Murphy R, Merriman TR. Krishnan M, et al. Among authors: major tj. Diabetologia. 2018 Jul;61(7):1603-1613. doi: 10.1007/s00125-018-4623-1. Epub 2018 May 2. Diabetologia. 2018. PMID: 29721634 Free PMC article.
An update on the genetics of hyperuricaemia and gout.
Major TJ, Dalbeth N, Stahl EA, Merriman TR. Major TJ, et al. Nat Rev Rheumatol. 2018 Jun;14(6):341-353. doi: 10.1038/s41584-018-0004-x. Nat Rev Rheumatol. 2018. PMID: 29740155 Review.
The relationship between ferritin and urate levels and risk of gout.
Fatima T, McKinney C, Major TJ, Stamp LK, Dalbeth N, Iverson C, Merriman TR, Miner JN. Fatima T, et al. Among authors: major tj. Arthritis Res Ther. 2018 Aug 15;20(1):179. doi: 10.1186/s13075-018-1668-y. Arthritis Res Ther. 2018. PMID: 30111358 Free PMC article.
Pleiotropic effect of the ABCG2 gene in gout: involvement in serum urate levels and progression from hyperuricemia to gout.
Wrigley R, Phipps-Green AJ, Topless RK, Major TJ, Cadzow M, Riches P, Tausche AK, Janssen M, Joosten LAB, Jansen TL, So A, Harré Hindmarsh J, Stamp LK, Dalbeth N, Merriman TR. Wrigley R, et al. Among authors: major tj. Arthritis Res Ther. 2020 Mar 12;22(1):45. doi: 10.1186/s13075-020-2136-z. Arthritis Res Ther. 2020. PMID: 32164793 Free PMC article.
Subtype-specific gout susceptibility loci and enrichment of selection pressure on ABCG2 and ALDH2 identified by subtype genome-wide meta-analyses of clinically defined gout patients.
Nakayama A, Nakatochi M, Kawamura Y, Yamamoto K, Nakaoka H, Shimizu S, Higashino T, Koyama T, Hishida A, Kuriki K, Watanabe M, Shimizu T, Ooyama K, Ooyama H, Nagase M, Hidaka Y, Matsui D, Tamura T, Nishiyama T, Shimanoe C, Katsuura-Kamano S, Takashima N, Shirai Y, Kawaguchi M, Takao M, Sugiyama R, Takada Y, Nakamura T, Nakashima H, Tsunoda M, Danjoh I, Hozawa A, Hosomichi K, Toyoda Y, Kubota Y, Takada T, Suzuki H, Stiburkova B, Major TJ, Merriman TR, Kuriyama N, Mikami H, Takezaki T, Matsuo K, Suzuki S, Hosoya T, Kamatani Y, Kubo M, Ichida K, Wakai K, Inoue I, Okada Y, Shinomiya N, Matsuo H; Japan Gout Genomics Consortium (Japan Gout). Nakayama A, et al. Among authors: major tj. Ann Rheum Dis. 2020 May;79(5):657-665. doi: 10.1136/annrheumdis-2019-216644. Epub 2020 Apr 1. Ann Rheum Dis. 2020. PMID: 32238385 Free PMC article.
Trans-ancestral dissection of urate- and gout-associated major loci SLC2A9 and ABCG2 reveals primate-specific regulatory effects.
Takei R, Cadzow M, Markie D, Bixley M, Phipps-Green A, Major TJ, Li C, Choi HK, Li Z, Hu H; Eurogout Consortium; Guo H, He M, Shi Y, Stamp LK, Dalbeth N, Merriman TR, Wei WH. Takei R, et al. Among authors: major tj. J Hum Genet. 2021 Feb;66(2):161-169. doi: 10.1038/s10038-020-0821-z. Epub 2020 Aug 10. J Hum Genet. 2021. PMID: 32778763
22 results