Manser K - Search Results

1

Synthesis and study of alendronate derivatives as potential prodrugs of alendronate sodium for the treatment of low bone density and osteoporosis.

Vachal P, Hale JJ, Lu Z, Streckfuss EC, Mills SG, MacCoss M, Yin DH, Algayer K, Manser K, Kesisoglou F, Ghosh S, Alani LL. Vachal P, et al. Among authors: manser k. J Med Chem. 2006 Jun 1;49(11):3060-3. doi: 10.1021/jm060398v. J Med Chem. 2006. PMID: 16722624

2

Utility of PBPK Absorption Modeling to Guide Modified Release Formulation Development of Gaboxadol, a Highly Soluble Compound With Region-Dependent Absorption.

Kesisoglou F, Balakrishnan A, Manser K. Kesisoglou F, et al. Among authors: manser k. J Pharm Sci. 2016 Feb;105(2):722-728. doi: 10.1002/jps.24674. Epub 2016 Jan 11. J Pharm Sci. 2016. PMID: 26457884

3

Suitability of a minipig model in assessing clinical bioperformance of matrix and multiparticulate extended-release formulations for a BCS class III Drug development candidate.

Kesisoglou F, Xie IH, Manser K, Wu Y, Hardy I, Fitzpatrick S. Kesisoglou F, et al. Among authors: manser k. J Pharm Sci. 2014 Feb;103(2):636-42. doi: 10.1002/jps.23837. Epub 2013 Dec 30. J Pharm Sci. 2014. PMID: 24382706 Clinical Trial.

4

Discovery of MK-8970: an acetal carbonate prodrug of raltegravir with enhanced colonic absorption.

Walji AM, Sanchez RI, Clas SD, Nofsinger R, de Lera Ruiz M, Li J, Bennet A, John C, Bennett DJ, Sanders JM, Di Marco CN, Kim SH, Balsells J, Ceglia SS, Dang Q, Manser K, Nissley B, Wai JS, Hafey M, Wang J, Chessen G, Templeton A, Higgins J, Smith R, Wu Y, Grobler J, Coleman PJ. Walji AM, et al. Among authors: manser k. ChemMedChem. 2015 Feb;10(2):245-52. doi: 10.1002/cmdc.201402393. Epub 2014 Dec 2. ChemMedChem. 2015. PMID: 25469982

5

Physicochemical properties, form, and formulation selection strategy for a biopharmaceutical classification system class II preclinical drug candidate.

Lohani S, Cooper H, Jin X, Nissley BP, Manser K, Rakes LH, Cummings JJ, Fauty SE, Bak A. Lohani S, et al. Among authors: manser k. J Pharm Sci. 2014 Oct;103(10):3007-21. doi: 10.1002/jps.24088. Epub 2014 Jul 29. J Pharm Sci. 2014. PMID: 25074668

6

Analysis of the absorption kinetics of macromolecules following intradermal and subcutaneous administration.

Milewski M, Manser K, Nissley BP, Mitra A. Milewski M, et al. Among authors: manser k. Eur J Pharm Biopharm. 2015 Jan;89:134-44. doi: 10.1016/j.ejpb.2014.11.013. Epub 2014 Nov 26. Eur J Pharm Biopharm. 2015. PMID: 25460581

7

Design of prodrugs to enhance colonic absorption by increasing lipophilicity and blocking ionization.

Nofsinger R, Clas SD, Sanchez RI, Walji A, Manser K, Nissley B, Balsells J, Nair A, Dang Q, Bennett DJ, Hafey M, Wang J, Higgins J, Templeton A, Coleman P, Grobler J, Smith R, Wu Y. Nofsinger R, et al. Among authors: manser k. Pharmaceuticals (Basel). 2014 Feb 24;7(2):207-19. doi: 10.3390/ph7020207. Pharmaceuticals (Basel). 2014. PMID: 24566521 Free PMC article.

8

Model-based decision making in early clinical development: minimizing the impact of a blood pressure adverse event.

Stroh M, Addy C, Wu Y, Stoch SA, Pourkavoos N, Groff M, Xu Y, Wagner J, Gottesdiener K, Shadle C, Wang H, Manser K, Winchell GA, Stone JA. Stroh M, et al. Among authors: manser k. AAPS J. 2009 Mar;11(1):99-108. doi: 10.1208/s12248-009-9083-6. Epub 2009 Feb 6. AAPS J. 2009. PMID: 19199043 Free PMC article.

9

Use of minipig skin biopsy model as an innovative tool to design topical formulation to achieve desired pharmacokinetics in humans.

Mitra A, Leyes A, Manser K, Roadcap B, Mestre C, Tatosian D, Jin L, Uemura N. Mitra A, et al. Among authors: manser k. J Pharm Sci. 2015 May;104(5):1701-8. doi: 10.1002/jps.24383. Epub 2015 Feb 17. J Pharm Sci. 2015. PMID: 25691117

10

Application of in vitro transmucosal permeability, dose number, and maximum absorbable dose for biopharmaceutics assessment during early drug development for intraoral delivery.

Yang Z, Sotthivirat S, Wu Y, Lalloo A, Nissley B, Manser K, Li H. Yang Z, et al. Among authors: manser k. Int J Pharm. 2016 Apr 30;503(1-2):78-89. doi: 10.1016/j.ijpharm.2016.02.033. Epub 2016 Feb 22. Int J Pharm. 2016. PMID: 26906458

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