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Increased volume of distribution for recombinant activated factor VII and longer plasma-derived factor VII half-life may explain their long lasting prophylactic effect.
Mathijssen NC, Masereeuw R, Holme PA, van Kraaij MG, Laros-van Gorkom BA, Peyvandi F, van Heerde WL. Mathijssen NC, et al. Among authors: masereeuw r. Thromb Res. 2013 Aug;132(2):256-62. doi: 10.1016/j.thromres.2013.05.027. Epub 2013 Jul 6. Thromb Res. 2013. PMID: 23834817 Free article. Clinical Trial.
Pharmacokinetic Modeling and Dose Selection in a Randomized, Double-Blind, Placebo-Controlled Trial of a Human Recombinant Alkaline Phosphatase in Healthy Volunteers.
Peters E, Heuberger JAAC, Tiessen R, van Elsas A, Masereeuw R, Arend J, Stevens J, Pickkers P. Peters E, et al. Among authors: masereeuw r. Clin Pharmacokinet. 2016 Oct;55(10):1227-1237. doi: 10.1007/s40262-016-0399-y. Clin Pharmacokinet. 2016. PMID: 27147514 Free PMC article. Clinical Trial.
262 results