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Increased volume of distribution for recombinant activated factor VII and longer plasma-derived factor VII half-life may explain their long lasting prophylactic effect.
Thromb Res. 2013 Aug;132(2):256-62. doi: 10.1016/j.thromres.2013.05.027. Epub 2013 Jul 6.
Thromb Res. 2013.
PMID: 23834817
Free article.
Clinical Trial.
Prophylactic effect of recombinant factor VIIa in factor VII deficient patients.
Mathijssen NC, Masereeuw R, Verbeek K, Lavergne JM, Costa JM, van Heerde WL, Nováková IR.
Mathijssen NC, et al.
Br J Haematol. 2004 May;125(4):494-9. doi: 10.1111/j.1365-2141.2004.04942.x.
Br J Haematol. 2004.
PMID: 15142120
Free article.
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Pharmacodynamics of recombinant activated factor VII and plasma-derived factor VII in a cohort of severe FVII deficient patients.
van Geffen M, Mathijssen NC, Holme PA, Laros-van Gorkom BA, van Kraaij MG, Masereeuw R, Peyvandi F, van Heerde WL.
van Geffen M, et al. Among authors: mathijssen nc.
Thromb Res. 2013 Jul;132(1):116-22. doi: 10.1016/j.thromres.2013.04.021. Epub 2013 May 31.
Thromb Res. 2013.
PMID: 23731565
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