Messer WS - Search Results

1

Effects of the Partial M1 Muscarinic Cholinergic Receptor Agonist CDD-0102A on Stereotyped Motor Behaviors and Reversal Learning in the BTBR Mouse Model of Autism.

Athnaiel O, Job GA, Ocampo R, Teneqexhi P, Messer WS, Ragozzino ME. Athnaiel O, et al. Among authors: messer ws. Int J Neuropsychopharmacol. 2022 Jan 12;25(1):64-74. doi: 10.1093/ijnp/pyab079. Int J Neuropsychopharmacol. 2022. PMID: 34791301 Free PMC article.

2

The selective M1 muscarinic cholinergic agonist CDD-0102A enhances working memory and cognitive flexibility.

Ragozzino ME, Artis S, Singh A, Twose TM, Beck JE, Messer WS Jr. Ragozzino ME, et al. Among authors: messer ws jr. J Pharmacol Exp Ther. 2012 Mar;340(3):588-94. doi: 10.1124/jpet.111.187625. Epub 2011 Dec 1. J Pharmacol Exp Ther. 2012. PMID: 22135384 Free PMC article.

3

Design, synthesis, and neurochemical evaluation of 5-(3-alkyl-1,2,4- oxadiazol-5-yl)-1,4,5,6-tetrahydropyrimidines as M1 muscarinic receptor agonists.

Dunbar PG, Durant GJ, Fang Z, Abuh YF, el-Assadi AA, Ngur DO, Periyasamy S, Hoss WP, Messer WS Jr. Dunbar PG, et al. Among authors: messer ws jr. J Med Chem. 1993 Apr 2;36(7):842-7. doi: 10.1021/jm00059a008. J Med Chem. 1993. PMID: 8464038

4

Synthesis and biochemical activity of novel amidine derivatives as m1 muscarinic receptor agonists.

Ojo B, Dunbar PG, Durant GJ, Nagy PI, Huzl JJ 3rd, Periyasamy S, Ngur DO, el-Assadi AA, Hoss WP, Messer WS Jr. Ojo B, et al. Among authors: messer ws jr. Bioorg Med Chem. 1996 Oct;4(10):1605-15. doi: 10.1016/0968-0896(96)00152-6. Bioorg Med Chem. 1996. PMID: 8931930

5

Design and development of selective muscarinic agonists for the treatment of Alzheimer's disease: characterization of tetrahydropyrimidine derivatives and development of new approaches for improved affinity and selectivity for M1 receptors.

Messer WS Jr, Rajeswaran WG, Cao Y, Zhang HJ, el-Assadi AA, Dockery C, Liske J, O'Brien J, Williams FE, Huang XP, Wroblewski ME, Nagy PI, Peseckis SM. Messer WS Jr, et al. Pharm Acta Helv. 2000 Mar;74(2-3):135-40. doi: 10.1016/s0031-6865(99)00026-6. Pharm Acta Helv. 2000. PMID: 10812950

6

Roles of threonine 192 and asparagine 382 in agonist and antagonist interactions with M1 muscarinic receptors.

Huang XP, Nagy PI, Williams FE, Peseckis SM, Messer WS Jr. Huang XP, et al. Among authors: messer ws jr. Br J Pharmacol. 1999 Feb;126(3):735-45. doi: 10.1038/sj.bjp.0702301. Br J Pharmacol. 1999. PMID: 10188986 Free PMC article.

7

Synthesis and biological characterization of 1,4,5,6-tetrahydropyrimidine and 2-amino-3,4,5,6-tetrahydropyridine derivatives as selective m1 agonists.

Messer WS Jr, Abuh YF, Liu Y, Periyasamy S, Ngur DO, Edgar MA, El-Assadi AA, Sbeih S, Dunbar PG, Roknich S, Rho T, Fang Z, Ojo B, Zhang H, Huzl JJ 3rd, Nagy PI. Messer WS Jr, et al. J Med Chem. 1997 Apr 11;40(8):1230-46. doi: 10.1021/jm960467d. J Med Chem. 1997. PMID: 9111297

8

Biochemical and behavioral responses of pilocarpine at muscarinic receptor subtypes in the CNS. Comparison with receptor binding and low-energy conformations.

Hoss W, Woodruff JM, Ellerbrock BR, Periyasamy S, Ghodsi-Hovsepian S, Stibbe J, Bohnett M, Messer WS Jr. Hoss W, et al. Among authors: messer ws jr. Brain Res. 1990 Nov 19;533(2):232-8. doi: 10.1016/0006-8993(90)91344-g. Brain Res. 1990. PMID: 1963109

9

Evidence for a preferential involvement of M1 muscarinic receptors in representational memory.

Messer WS Jr, Bohnett M, Stibbe J. Messer WS Jr, et al. Neurosci Lett. 1990 Aug 14;116(1-2):184-9. doi: 10.1016/0304-3940(90)90407-z. Neurosci Lett. 1990. PMID: 2259447

10

Evaluation of 1,2,5-thiadiazoles as modulators of M₁/M₅ muscarinic receptor subtypes.

Maheshwari A, Rao PS, Messer WS Jr. Maheshwari A, et al. Among authors: messer ws jr. Bioorg Med Chem. 2014 Mar 15;22(6):1838-44. doi: 10.1016/j.bmc.2014.01.049. Epub 2014 Feb 7. Bioorg Med Chem. 2014. PMID: 24582400

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