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TGF-β inhibitor therapy decreases fibrosis and stimulates cardiac improvement in a pre-clinical study of chronic Chagas' heart disease.
Ferreira RR, Abreu RDS, Vilar-Pereira G, Degrave W, Meuser-Batista M, Ferreira NVC, da Cruz Moreira O, da Silva Gomes NL, Mello de Souza E, Ramos IP, Bailly S, Feige JJ, Lannes-Vieira J, de Araújo-Jorge TC, Waghabi MC. Ferreira RR, et al. PLoS Negl Trop Dis. 2019 Jul 31;13(7):e0007602. doi: 10.1371/journal.pntd.0007602. eCollection 2019 Jul. PLoS Negl Trop Dis. 2019. PMID: 31365537 Free PMC article.
Mast cell function and death in Trypanosoma cruzi infection.
Meuser-Batista M, Corrêa JR, Carvalho VF, de Carvalho Britto CF, Moreira OC, Batista MM, Soares MJ, Filho FA, E Silva PM, Lannes-Vieira J, Silva RC, Henriques-Pons A. Meuser-Batista M, et al. Am J Pathol. 2011 Oct;179(4):1894-904. doi: 10.1016/j.ajpath.2011.06.014. Epub 2011 Aug 3. Am J Pathol. 2011. PMID: 21819958 Free PMC article.
4-aminopyridyl-based lead compounds targeting CYP51 prevent spontaneous parasite relapse in a chronic model and improve cardiac pathology in an acute model of Trypanosoma cruzi infection.
Calvet CM, Choi JY, Thomas D, Suzuki B, Hirata K, Lostracco-Johnson S, de Mesquita LB, Nogueira A, Meuser-Batista M, Silva TA, Siqueira-Neto JL, Roush WR, de Souza Pereira MC, McKerrow JH, Podust LM. Calvet CM, et al. PLoS Negl Trop Dis. 2017 Dec 27;11(12):e0006132. doi: 10.1371/journal.pntd.0006132. eCollection 2017 Dec. PLoS Negl Trop Dis. 2017. PMID: 29281643 Free PMC article.
Antiparasitic and anti-inflammatory activities of ß-lapachone-derived naphthoimidazoles in experimental acute Trypanosoma cruzi infection.
Cascabulho CM, Meuser-Batista M, Moura KCG, Pinto MDC, Duque TLA, Demarque KC, Guimarães ACR, Manso PPA, Pelajo-Machado M, Oliveira GM, Castro SL, Menna-Barreto RF. Cascabulho CM, et al. Mem Inst Oswaldo Cruz. 2020 Feb 14;115:e190389. doi: 10.1590/0074-02760190389. eCollection 2020. Mem Inst Oswaldo Cruz. 2020. PMID: 32074167 Free PMC article.
Inhibition of Brazilian ZIKV strain replication in primary human placental chorionic cells and cervical cells treated with nitazoxanide.
de Souza AAA, Torres LR, Lima LRP, de Paula V, Barros JJ, Bonecini-Almeida MDG, Waghabi MC, Gardel MA, Meuser-Batista M, de Souza EM. de Souza AAA, et al. Among authors: meuser batista m. Braz J Infect Dis. 2020 Nov-Dec;24(6):505-516. doi: 10.1016/j.bjid.2020.09.001. Epub 2020 Sep 30. Braz J Infect Dis. 2020. PMID: 33010209 Free PMC article.
In Chagas disease, transforming growth factor beta neutralization reduces Trypanosoma cruzi infection and improves cardiac performance.
Ferreira RR, de Souza EM, Vilar-Pereira G, Degrave WMS, Abreu RDS, Meuser-Batista M, Ferreira NVC, Ledbeter S, Barker RH, Bailly S, Feige JJ, Lannes-Vieira J, de Araújo-Jorge TC, Waghabi MC. Ferreira RR, et al. Among authors: meuser batista m. Front Cell Infect Microbiol. 2022 Nov 30;12:1017040. doi: 10.3389/fcimb.2022.1017040. eCollection 2022. Front Cell Infect Microbiol. 2022. PMID: 36530434 Free PMC article.
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