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TDP-43 loss of function inhibits endosomal trafficking and alters trophic signaling in neurons.
Schwenk BM, Hartmann H, Serdaroglu A, Schludi MH, Hornburg D, Meissner F, Orozco D, Colombo A, Tahirovic S, Michaelsen M, Schreiber F, Haupt S, Peitz M, Brüstle O, Küpper C, Klopstock T, Otto M, Ludolph AC, Arzberger T, Kuhn PH, Edbauer D. Schwenk BM, et al. Among authors: michaelsen m. EMBO J. 2016 Nov 2;35(21):2350-2370. doi: 10.15252/embj.201694221. Epub 2016 Sep 12. EMBO J. 2016. PMID: 27621269 Free PMC article.
Antibodies inhibit transmission and aggregation of C9orf72 poly-GA dipeptide repeat proteins.
Zhou Q, Lehmer C, Michaelsen M, Mori K, Alterauge D, Baumjohann D, Schludi MH, Greiling J, Farny D, Flatley A, Feederle R, May S, Schreiber F, Arzberger T, Kuhm C, Klopstock T, Hermann A, Haass C, Edbauer D. Zhou Q, et al. Among authors: michaelsen m. EMBO Mol Med. 2017 May;9(5):687-702. doi: 10.15252/emmm.201607054. EMBO Mol Med. 2017. PMID: 28351931 Free PMC article.
Spinal poly-GA inclusions in a C9orf72 mouse model trigger motor deficits and inflammation without neuron loss.
Schludi MH, Becker L, Garrett L, Gendron TF, Zhou Q, Schreiber F, Popper B, Dimou L, Strom TM, Winkelmann J, von Thaden A, Rentzsch K, May S, Michaelsen M, Schwenk BM, Tan J, Schoser B, Dieterich M, Petrucelli L, Hölter SM, Wurst W, Fuchs H, Gailus-Durner V, de Angelis MH, Klopstock T, Arzberger T, Edbauer D. Schludi MH, et al. Among authors: michaelsen m. Acta Neuropathol. 2017 Aug;134(2):241-254. doi: 10.1007/s00401-017-1711-0. Epub 2017 Apr 13. Acta Neuropathol. 2017. PMID: 28409281 Free PMC article.
Active poly-GA vaccination prevents microglia activation and motor deficits in a C9orf72 mouse model.
Zhou Q, Mareljic N, Michaelsen M, Parhizkar S, Heindl S, Nuscher B, Farny D, Czuppa M, Schludi C, Graf A, Krebs S, Blum H, Feederle R, Roth S, Haass C, Arzberger T, Liesz A, Edbauer D. Zhou Q, et al. Among authors: michaelsen m. EMBO Mol Med. 2020 Feb 7;12(2):e10919. doi: 10.15252/emmm.201910919. Epub 2019 Dec 20. EMBO Mol Med. 2020. PMID: 31858749 Free PMC article.
Cell-to-cell transmission of C9orf72 poly-(Gly-Ala) triggers key features of ALS/FTD.
Khosravi B, LaClair KD, Riemenschneider H, Zhou Q, Frottin F, Mareljic N, Czuppa M, Farny D, Hartmann H, Michaelsen M, Arzberger T, Hartl FU, Hipp MS, Edbauer D. Khosravi B, et al. Among authors: michaelsen m. EMBO J. 2020 Apr 15;39(8):e102811. doi: 10.15252/embj.2019102811. Epub 2020 Mar 16. EMBO J. 2020. PMID: 32175624 Free PMC article.
Congenic expression of poly-GA but not poly-PR in mice triggers selective neuron loss and interferon responses found in C9orf72 ALS.
LaClair KD, Zhou Q, Michaelsen M, Wefers B, Brill MS, Janjic A, Rathkolb B, Farny D, Cygan M, de Angelis MH, Wurst W, Neumann M, Enard W, Misgeld T, Arzberger T, Edbauer D. LaClair KD, et al. Among authors: michaelsen m. Acta Neuropathol. 2020 Aug;140(2):121-142. doi: 10.1007/s00401-020-02176-0. Epub 2020 Jun 19. Acta Neuropathol. 2020. PMID: 32562018 Free PMC article.
Targeting the glycine-rich domain of TDP-43 with antibodies prevents its aggregation in vitro and reduces neurofilament levels in vivo.
Riemenschneider H, Simonetti F, Sheth U, Katona E, Roth S, Hutten S, Farny D, Michaelsen M, Nuscher B, Schmidt MK, Flatley A, Schepers A, Gruijs da Silva LA, Zhou Q, Klopstock T, Liesz A, Arzberger T, Herms J, Feederle R, Gendron TF, Dormann D, Edbauer D. Riemenschneider H, et al. Among authors: michaelsen m. Acta Neuropathol Commun. 2023 Jul 11;11(1):112. doi: 10.1186/s40478-023-01592-z. Acta Neuropathol Commun. 2023. PMID: 37434215 Free PMC article.
42 results