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Hyper-activation of Notch3 amplifies the proliferative potential of rhabdomyosarcoma cells.
De Salvo M, Raimondi L, Vella S, Adesso L, Ciarapica R, Verginelli F, Pannuti A, Citti A, Boldrini R, Milano GM, Cacchione A, Ferrari A, Collini P, Rosolen A, Bisogno G, Alaggio R, Inserra A, Locatelli M, Stifani S, Screpanti I, Miele L, Locatelli F, Rota R. De Salvo M, et al. Among authors: miele l. PLoS One. 2014 May 5;9(5):e96238. doi: 10.1371/journal.pone.0096238. eCollection 2014. PLoS One. 2014. PMID: 24797362 Free PMC article.
Notch-1 associates with IKKalpha and regulates IKK activity in cervical cancer cells.
Song LL, Peng Y, Yun J, Rizzo P, Chaturvedi V, Weijzen S, Kast WM, Stone PJ, Santos L, Loredo A, Lendahl U, Sonenshein G, Osborne B, Qin JZ, Pannuti A, Nickoloff BJ, Miele L. Song LL, et al. Among authors: miele l. Oncogene. 2008 Oct 2;27(44):5833-44. doi: 10.1038/onc.2008.190. Epub 2008 Jun 16. Oncogene. 2008. PMID: 18560356
Targeting Notch to target cancer stem cells.
Pannuti A, Foreman K, Rizzo P, Osipo C, Golde T, Osborne B, Miele L. Pannuti A, et al. Among authors: miele l. Clin Cancer Res. 2010 Jun 15;16(12):3141-52. doi: 10.1158/1078-0432.CCR-09-2823. Epub 2010 Jun 8. Clin Cancer Res. 2010. PMID: 20530696 Free PMC article. Review.
Inhibition of Notch3 signalling induces rhabdomyosarcoma cell differentiation promoting p38 phosphorylation and p21(Cip1) expression and hampers tumour cell growth in vitro and in vivo.
Raimondi L, Ciarapica R, De Salvo M, Verginelli F, Gueguen M, Martini C, De Sio L, Cortese G, Locatelli M, Dang TP, Carlesso N, Miele L, Stifani S, Limon I, Locatelli F, Rota R. Raimondi L, et al. Among authors: miele l. Cell Death Differ. 2012 May;19(5):871-81. doi: 10.1038/cdd.2011.171. Epub 2011 Nov 25. Cell Death Differ. 2012. PMID: 22117196 Free PMC article.
540 results