Miller RR - Search Results

1

Discovery of a potent, orally bioavailable beta(3) adrenergic receptor agonist, (R)-N-[4-[2-[[2-hydroxy-2-(3-pyridinyl)ethyl]amino]ethyl]phenyl]-4-[4 -[4-(trifluoromethyl)phenyl]thiazol-2-yl]benzenesulfonamide.

Mathvink RJ, Tolman JS, Chitty D, Candelore MR, Cascieri MA, Colwell LF Jr, Deng L, Feeney WP, Forrest MJ, Hom GJ, MacIntyre DE, Miller RR, Stearns RA, Tota L, Wyvratt MJ, Fisher MH, Weber AE. Mathvink RJ, et al. Among authors: miller rr. J Med Chem. 2000 Oct 19;43(21):3832-6. doi: 10.1021/jm000286i. J Med Chem. 2000. PMID: 11052788

2

The metabolism of DuP 753, a nonpeptide angiotensin II receptor antagonist, by rat, monkey, and human liver slices.

Stearns RA, Miller RR, Doss GA, Chakravarty PK, Rosegay A, Gatto GJ, Chiu SH. Stearns RA, et al. Among authors: miller rr. Drug Metab Dispos. 1992 Mar-Apr;20(2):281-7. Drug Metab Dispos. 1992. PMID: 1352222

3

Synthesis and identification of a novel tetrazole metabolite of the angiotensin II receptor antagonist DuP 753.

Stearns RA, Doss GA, Miller RR, Chiu SH. Stearns RA, et al. Among authors: miller rr. Drug Metab Dispos. 1991 Nov-Dec;19(6):1160-2. Drug Metab Dispos. 1991. PMID: 1687025 No abstract available.

4

Metabolites of L-735,524, a potent HIV-1 protease inhibitor, in human urine.

Balani SK, Arison BH, Mathai L, Kauffman LR, Miller RR, Stearns RA, Chen IW, Lin JH. Balani SK, et al. Among authors: miller rr. Drug Metab Dispos. 1995 Feb;23(2):266-70. Drug Metab Dispos. 1995. PMID: 7736923 Clinical Trial.

5

Absorption and glucuronidation of the angiotensin II receptor antagonist losartan by the rat intestine.

Krieter PA, Colletti AE, Miller RR, Stearns RA. Krieter PA, et al. Among authors: miller rr. J Pharmacol Exp Ther. 1995 May;273(2):816-22. J Pharmacol Exp Ther. 1995. PMID: 7752085

6

Evidence for a 1,2-hydride shift in the microsomal metabolism of the heterocycle L-158,338, a nonpeptide angiotensin II receptor antagonist.

Stearns RA, Miller RR, Arison BH, Rosegay A, Smith JL, Mantlo NB, Chiu SH. Stearns RA, et al. Among authors: miller rr. Drug Metab Dispos. 1993 Jul-Aug;21(4):670-6. Drug Metab Dispos. 1993. PMID: 8104127

7

Pharmacokinetics and disposition of L-692,429. A novel nonpeptidyl growth hormone secretagogue in preclinical species.

Leung KH, Cohn DA, Miller RR, Doss GA, Stearns RA, Simpson RE, Feeney WP, Chiu SH. Leung KH, et al. Among authors: miller rr. Drug Metab Dispos. 1996 Jul;24(7):753-60. Drug Metab Dispos. 1996. PMID: 8818572

8

Pharmacokinetics and disposition of the oxytocin receptor antagonist L-368,899 in rats and dogs.

Thompson KL, Vincent SH, Miller RR, Colletti AE, Alvaro RF, Wallace MA, Feeney WP, Chiu SH. Thompson KL, et al. Among authors: miller rr. Drug Metab Dispos. 1997 Oct;25(10):1113-8. Drug Metab Dispos. 1997. PMID: 9321512

9

A selective human beta3 adrenergic receptor agonist increases metabolic rate in rhesus monkeys.

Fisher MH, Amend AM, Bach TJ, Barker JM, Brady EJ, Candelore MR, Carroll D, Cascieri MA, Chiu SH, Deng L, Forrest MJ, Hegarty-Friscino B, Guan XM, Hom GJ, Hutchins JE, Kelly LJ, Mathvink RJ, Metzger JM, Miller RR, Ok HO, Parmee ER, Saperstein R, Strader CD, Stearns RA, MacIntyre DE, et al. Fisher MH, et al. Among authors: miller rr. J Clin Invest. 1998 Jun 1;101(11):2387-93. doi: 10.1172/JCI2496. J Clin Invest. 1998. PMID: 9616210 Free PMC article.

10

Disposition of L-732,531, a potent immunosuppressant, in rats and baboons.

Karanam BV, Miller RR, Colletti A, Montgomery T, Carey KD, Hawkins T, Tang YS, Lavin M, Stearns RA, Chiu SH, Vincent SH. Karanam BV, et al. Among authors: miller rr. Drug Metab Dispos. 1998 Oct;26(10):949-57. Drug Metab Dispos. 1998. PMID: 9763399

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