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The unique hypusine modification of eIF5A promotes islet beta cell inflammation and dysfunction in mice.
Maier B, Ogihara T, Trace AP, Tersey SA, Robbins RD, Chakrabarti SK, Nunemaker CS, Stull ND, Taylor CA, Thompson JE, Dondero RS, Lewis EC, Dinarello CA, Nadler JL, Mirmira RG. Maier B, et al. Among authors: mirmira rg. J Clin Invest. 2010 Jun;120(6):2156-70. doi: 10.1172/JCI38924. Epub 2010 May 24. J Clin Invest. 2010. PMID: 20501948 Free PMC article.
Deletion of 12/15-lipoxygenase alters macrophage and islet function in NOD-Alox15(null) mice, leading to protection against type 1 diabetes development.
Green-Mitchell SM, Tersey SA, Cole BK, Ma K, Kuhn NS, Cunningham TD, Maybee NA, Chakrabarti SK, McDuffie M, Taylor-Fishwick DA, Mirmira RG, Nadler JL, Morris MA. Green-Mitchell SM, et al. Among authors: mirmira rg. PLoS One. 2013;8(2):e56763. doi: 10.1371/journal.pone.0056763. Epub 2013 Feb 21. PLoS One. 2013. PMID: 23437231 Free PMC article.
Mouse and human islets survive and function after coating by biosilicification.
Jaroch DB, Lu J, Madangopal R, Stull ND, Stensberg M, Shi J, Kahn JL, Herrera-Perez R, Zeitchek M, Sturgis J, Robinson JP, Yoder MC, Porterfield DM, Mirmira RG, Rickus JL. Jaroch DB, et al. Among authors: mirmira rg. Am J Physiol Endocrinol Metab. 2013 Nov 15;305(10):E1230-40. doi: 10.1152/ajpendo.00081.2013. Epub 2013 Sep 3. Am J Physiol Endocrinol Metab. 2013. PMID: 24002572 Free PMC article.
192 results