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Mitochondrial health is enhanced in rats with higher vs. lower intrinsic exercise capacity and extended lifespan.
Aon MA, Cortassa S, Juhaszova M, González-Reyes JA, Calvo-Rubio M, Villalba JM, Lachance AD, Ziman BD, Mitchell SJ, Murt KN, Axsom JEC, Alfaras I, Britton SL, Koch LG, de Cabo R, Lakatta EG, Sollott SJ. Aon MA, et al. Among authors: mitchell sj. NPJ Aging Mech Dis. 2021 Jan 4;7(1):1. doi: 10.1038/s41514-020-00054-3. NPJ Aging Mech Dis. 2021. PMID: 33398019 Free PMC article.
Metformin improves healthspan and lifespan in mice.
Martin-Montalvo A, Mercken EM, Mitchell SJ, Palacios HH, Mote PL, Scheibye-Knudsen M, Gomes AP, Ward TM, Minor RK, Blouin MJ, Schwab M, Pollak M, Zhang Y, Yu Y, Becker KG, Bohr VA, Ingram DK, Sinclair DA, Wolf NS, Spindler SR, Bernier M, de Cabo R. Martin-Montalvo A, et al. Among authors: mitchell sj. Nat Commun. 2013;4:2192. doi: 10.1038/ncomms3192. Nat Commun. 2013. PMID: 23900241 Free PMC article.
The SIRT1 activator SRT1720 extends lifespan and improves health of mice fed a standard diet.
Mitchell SJ, Martin-Montalvo A, Mercken EM, Palacios HH, Ward TM, Abulwerdi G, Minor RK, Vlasuk GP, Ellis JL, Sinclair DA, Dawson J, Allison DB, Zhang Y, Becker KG, Bernier M, de Cabo R. Mitchell SJ, et al. Cell Rep. 2014 Mar 13;6(5):836-43. doi: 10.1016/j.celrep.2014.01.031. Epub 2014 Feb 27. Cell Rep. 2014. PMID: 24582957 Free PMC article.
SRT2104 extends survival of male mice on a standard diet and preserves bone and muscle mass.
Mercken EM, Mitchell SJ, Martin-Montalvo A, Minor RK, Almeida M, Gomes AP, Scheibye-Knudsen M, Palacios HH, Licata JJ, Zhang Y, Becker KG, Khraiwesh H, González-Reyes JA, Villalba JM, Baur JA, Elliott P, Westphal C, Vlasuk GP, Ellis JL, Sinclair DA, Bernier M, de Cabo R. Mercken EM, et al. Among authors: mitchell sj. Aging Cell. 2014 Oct;13(5):787-96. doi: 10.1111/acel.12220. Epub 2014 Jun 16. Aging Cell. 2014. PMID: 24931715 Free PMC article.
Factors that Impact on Interrater Reliability of the Mouse Clinical Frailty Index.
Kane AE, Hilmer SN, Huizer-Pajkos A, Mach J, Nines D, Boyer D, Gavin K, Mitchell SJ, de Cabo R. Kane AE, et al. Among authors: mitchell sj. J Gerontol A Biol Sci Med Sci. 2015 Jun;70(6):694-5. doi: 10.1093/gerona/glv032. Epub 2015 Apr 2. J Gerontol A Biol Sci Med Sci. 2015. PMID: 25838548 Free PMC article. No abstract available.
Macronutrients and caloric intake in health and longevity.
Solon-Biet SM, Mitchell SJ, de Cabo R, Raubenheimer D, Le Couteur DG, Simpson SJ. Solon-Biet SM, et al. Among authors: mitchell sj. J Endocrinol. 2015 Jul;226(1):R17-28. doi: 10.1530/JOE-15-0173. Epub 2015 May 28. J Endocrinol. 2015. PMID: 26021555 Free PMC article. Review.
The impact of low-protein high-carbohydrate diets on aging and lifespan.
Le Couteur DG, Solon-Biet S, Cogger VC, Mitchell SJ, Senior A, de Cabo R, Raubenheimer D, Simpson SJ. Le Couteur DG, et al. Among authors: mitchell sj. Cell Mol Life Sci. 2016 Mar;73(6):1237-52. doi: 10.1007/s00018-015-2120-y. Epub 2015 Dec 30. Cell Mol Life Sci. 2016. PMID: 26718486 Review.
372 results