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Potent cyclic peptide inhibitors of VLA-4 (alpha4beta1 integrin)-mediated cell adhesion. Discovery of compounds like cyclo(MePhe-Leu-Asp-Val-D-Arg-D-Arg) (ZD7349) compatible with depot formulation.
J Pept Sci. 2000 Aug;6(8):398-412. doi: 10.1002/1099-1387(200008)6:8<398::AID-PSC270>3.0.CO;2-1.
J Pept Sci. 2000.
PMID: 10969869
Potent cyclic monomeric and dimeric peptide inhibitors of VLA-4 (alpha4beta1 integrin)-mediated cell adhesion based on the Ile-Leu-Asp-Val tetrapeptide.
Dutta AS, Crowther M, Gormley JJ, Hassall L, Hayward CF, Gellert PR, Kittlety RS, Alcock PJ, Jamieson A, Moores JM, Rees A, Wood LJ, Reilly CF, Haworth D.
Dutta AS, et al. Among authors: moores jm.
J Pept Sci. 2000 Jul;6(7):321-41. doi: 10.1002/1099-1387(200007)6:7<321::AID-PSC259>3.0.CO;2-A.
J Pept Sci. 2000.
PMID: 10946997
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A comparison of the effects of aspirin on bleeding time measured using the Simplate method and closure time measured using the PFA-100, in healthy volunteers.
Marshall PW, Williams AJ, Dixon RM, Growcott JW, Warburton S, Armstrong J, Moores J.
Marshall PW, et al.
Br J Clin Pharmacol. 1997 Aug;44(2):151-5. doi: 10.1046/j.1365-2125.1997.00639.x.
Br J Clin Pharmacol. 1997.
PMID: 9278200
Free PMC article.
Clinical Trial.
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