Moraes AH - Search Results

1

Anomalous structural dynamics of minimally frustrated residues in cardiac troponin C triggers hypertrophic cardiomyopathy.

Marques MA, Landim-Vieira M, Moraes AH, Sun B, Johnston JR, Dieseldorff Jones KM, Cino EA, Parvatiyar MS, Valera IC, Silva JL, Galkin VE, Chase PB, Kekenes-Huskey PM, de Oliveira GAP, Pinto JR. Marques MA, et al. Among authors: moraes ah. Chem Sci. 2021 Apr 29;12(21):7308-7323. doi: 10.1039/d1sc01886h. Chem Sci. 2021. PMID: 34163821 Free PMC article.

2

The intrinsically disordered C terminus of troponin T binds to troponin C to modulate myocardial force generation.

Johnston JR, Landim-Vieira M, Marques MA, de Oliveira GAP, Gonzalez-Martinez D, Moraes AH, He H, Iqbal A, Wilnai Y, Birk E, Zucker N, Silva JL, Chase PB, Pinto JR. Johnston JR, et al. Among authors: moraes ah. J Biol Chem. 2019 Dec 27;294(52):20054-20069. doi: 10.1074/jbc.RA119.011177. Epub 2019 Nov 20. J Biol Chem. 2019. PMID: 31748410 Free PMC article.

3

Allosteric Transmission along a Loosely Structured Backbone Allows a Cardiac Troponin C Mutant to Function with Only One Ca²⁺ Ion.

Marques MA, Pinto JR, Moraes AH, Iqbal A, de Magalhães MT, Monteiro J, Pedrote MM, Sorenson MM, Silva JL, de Oliveira GA. Marques MA, et al. Among authors: moraes ah. J Biol Chem. 2017 Feb 10;292(6):2379-2394. doi: 10.1074/jbc.M116.765362. Epub 2017 Jan 3. J Biol Chem. 2017. PMID: 28049727 Free PMC article.

4

Amide hydrogens reveal a temperature-dependent structural transition that enhances site-II Ca²⁺-binding affinity in a C-domain mutant of cardiac troponin C.

Veltri T, de Oliveira GAP, Bienkiewicz EA, Palhano FL, Marques MA, Moraes AH, Silva JL, Sorenson MM, Pinto JR. Veltri T, et al. Among authors: moraes ah. Sci Rep. 2017 Apr 6;7(1):691. doi: 10.1038/s41598-017-00777-6. Sci Rep. 2017. PMID: 28386062 Free PMC article.

5

Conformational dynamics of Tetracenomycin aromatase/cyclase regulate polyketide binding and enzyme aggregation propensity.

Valadares VS, Martins LC, Roman EA, Valente AP, Cino EA, Moraes AH. Valadares VS, et al. Among authors: moraes ah. Biochim Biophys Acta Gen Subj. 2021 Sep;1865(9):129949. doi: 10.1016/j.bbagen.2021.129949. Epub 2021 Jun 15. Biochim Biophys Acta Gen Subj. 2021. PMID: 34139289

6

Structural basis for the dissociation of α-synuclein fibrils triggered by pressure perturbation of the hydrophobic core.

de Oliveira GA, Marques MA, Cruzeiro-Silva C, Cordeiro Y, Schuabb C, Moraes AH, Winter R, Oschkinat H, Foguel D, Freitas MS, Silva JL. de Oliveira GA, et al. Among authors: moraes ah. Sci Rep. 2016 Nov 30;6:37990. doi: 10.1038/srep37990. Sci Rep. 2016. PMID: 27901101 Free PMC article.

7

New Heteroleptic Ruthenium(II) Complexes with Sulfamethoxypyridazine and Diimines as Potential Antitumor Agents.

de Melo ACC, Santana JMSVP, Nunes KJRC, Rodrigues BL, Castilho N, Gabriel P, Moraes AH, Marques MA, de Oliveira GAP, de Souza ÍP, Terenzi H, Pereira-Maia EC. de Melo ACC, et al. Among authors: moraes ah. Molecules. 2019 Jun 7;24(11):2154. doi: 10.3390/molecules24112154. Molecules. 2019. PMID: 31181667 Free PMC article.

8

Dynamics and allostery of Zika virus non-structural protein 5 methyltransferase.

Chagas M, Rocha W, Moraes A. Chagas M, et al. J Biomol Struct Dyn. 2021 Sep;39(15):5526-5538. doi: 10.1080/07391102.2020.1792343. Epub 2020 Jul 16. J Biomol Struct Dyn. 2021. PMID: 32673148

9

Zika virus proteins at an atomic scale: how does structural biology help us to understand and develop vaccines and drugs against Zika virus infection?

Valente AP, Moraes AH. Valente AP, et al. Among authors: moraes ah. J Venom Anim Toxins Incl Trop Dis. 2019 Aug 29;25:e20190013. doi: 10.1590/1678-9199-JVATITD-2019-0013. J Venom Anim Toxins Incl Trop Dis. 2019. PMID: 31523227 Free PMC article. Review.

10

Structures of the reduced and oxidized state of the mutant D24A of yeast thioredoxin 1: insights into the mechanism for the closing of the water cavity.

Iqbal A, Moraes AH, Valente AP, Almeida FCL. Iqbal A, et al. Among authors: moraes ah. J Biomol NMR. 2015 Dec;63(4):417-423. doi: 10.1007/s10858-015-9996-6. Epub 2015 Oct 20. J Biomol NMR. 2015. PMID: 26482062 No abstract available.

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