Morgan RA - Search Results

1

Primary human T lymphocytes engineered with a codon-optimized IL-15 gene resist cytokine withdrawal-induced apoptosis and persist long-term in the absence of exogenous cytokine.

Hsu C, Hughes MS, Zheng Z, Bray RB, Rosenberg SA, Morgan RA. Hsu C, et al. Among authors: morgan ra. J Immunol. 2005 Dec 1;175(11):7226-34. doi: 10.4049/jimmunol.175.11.7226. J Immunol. 2005. PMID: 16301627 Free PMC article.

2

Lentiviral vector design for optimal T cell receptor gene expression in the transduction of peripheral blood lymphocytes and tumor-infiltrating lymphocytes.

Jones S, Peng PD, Yang S, Hsu C, Cohen CJ, Zhao Y, Abad J, Zheng Z, Rosenberg SA, Morgan RA. Jones S, et al. Among authors: morgan ra. Hum Gene Ther. 2009 Jun;20(6):630-40. doi: 10.1089/hum.2008.048. Hum Gene Ther. 2009. PMID: 19265475 Free PMC article.

3

Lack of specific gamma-retroviral vector long terminal repeat promoter silencing in patients receiving genetically engineered lymphocytes and activation upon lymphocyte restimulation.

Burns WR, Zheng Z, Rosenberg SA, Morgan RA. Burns WR, et al. Among authors: morgan ra. Blood. 2009 Oct 1;114(14):2888-99. doi: 10.1182/blood-2009-01-199216. Epub 2009 Jul 9. Blood. 2009. PMID: 19589923 Free PMC article.

4

A herceptin-based chimeric antigen receptor with modified signaling domains leads to enhanced survival of transduced T lymphocytes and antitumor activity.

Zhao Y, Wang QJ, Yang S, Kochenderfer JN, Zheng Z, Zhong X, Sadelain M, Eshhar Z, Rosenberg SA, Morgan RA. Zhao Y, et al. Among authors: morgan ra. J Immunol. 2009 Nov 1;183(9):5563-74. doi: 10.4049/jimmunol.0900447. J Immunol. 2009. PMID: 19843940 Free PMC article.

5

Both CD4 and CD8 T cells mediate equally effective in vivo tumor treatment when engineered with a highly avid TCR targeting tyrosinase.

Frankel TL, Burns WR, Peng PD, Yu Z, Chinnasamy D, Wargo JA, Zheng Z, Restifo NP, Rosenberg SA, Morgan RA. Frankel TL, et al. Among authors: morgan ra. J Immunol. 2010 Jun 1;184(11):5988-98. doi: 10.4049/jimmunol.1000189. Epub 2010 Apr 28. J Immunol. 2010. PMID: 20427771 Free PMC article.

6

A simplified method for the clinical-scale generation of central memory-like CD8+ T cells after transduction with lentiviral vectors encoding antitumor antigen T-cell receptors.

Yang S, Dudley ME, Rosenberg SA, Morgan RA. Yang S, et al. Among authors: morgan ra. J Immunother. 2010 Jul-Aug;33(6):648-58. doi: 10.1097/CJI.0b013e3181e311cb. J Immunother. 2010. PMID: 20551831 Free PMC article.

7

A TCR targeting the HLA-A*0201-restricted epitope of MAGE-A3 recognizes multiple epitopes of the MAGE-A antigen superfamily in several types of cancer.

Chinnasamy N, Wargo JA, Yu Z, Rao M, Frankel TL, Riley JP, Hong JJ, Parkhurst MR, Feldman SA, Schrump DS, Restifo NP, Robbins PF, Rosenberg SA, Morgan RA. Chinnasamy N, et al. Among authors: morgan ra. J Immunol. 2011 Jan 15;186(2):685-96. doi: 10.4049/jimmunol.1001775. Epub 2010 Dec 13. J Immunol. 2011. PMID: 21149604 Free PMC article.

8

Improving adoptive T cell therapy by targeting and controlling IL-12 expression to the tumor environment.

Zhang L, Kerkar SP, Yu Z, Zheng Z, Yang S, Restifo NP, Rosenberg SA, Morgan RA. Zhang L, et al. Among authors: morgan ra. Mol Ther. 2011 Apr;19(4):751-9. doi: 10.1038/mt.2010.313. Epub 2011 Feb 1. Mol Ther. 2011. PMID: 21285960 Free PMC article.

9

Treating cancer with genetically engineered T cells.

Park TS, Rosenberg SA, Morgan RA. Park TS, et al. Among authors: morgan ra. Trends Biotechnol. 2011 Nov;29(11):550-7. doi: 10.1016/j.tibtech.2011.04.009. Epub 2011 Jun 12. Trends Biotechnol. 2011. PMID: 21663987 Free PMC article. Review.

10

Evaluation of γ-retroviral vectors that mediate the inducible expression of IL-12 for clinical application.

Zhang L, Feldman SA, Zheng Z, Chinnasamy N, Xu H, Nahvi AV, Dudley ME, Rosenberg SA, Morgan RA. Zhang L, et al. Among authors: morgan ra. J Immunother. 2012 Jun;35(5):430-9. doi: 10.1097/CJI.0b013e31825898e8. J Immunother. 2012. PMID: 22576348 Free PMC article.

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