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MT5-MMP is a new pro-amyloidogenic proteinase that promotes amyloid pathology and cognitive decline in a transgenic mouse model of Alzheimer's disease.
Cell Mol Life Sci. 2016 Jan;73(1):217-36. doi: 10.1007/s00018-015-1992-1. Epub 2015 Jul 23.
Cell Mol Life Sci. 2016.
PMID: 26202697
Free PMC article.
MT5-MMP Promotes Alzheimer's Pathogenesis in the Frontal Cortex of 5xFAD Mice and APP Trafficking in vitro.
Baranger K, Bonnet AE, Girard SD, Paumier JM, García-González L, Elmanaa W, Bernard A, Charrat E, Stephan D, Bauer C, Moschke K, Lichtenthaler SF, Roman FS, Checler F, Khrestchatisky M, Rivera S.
Baranger K, et al. Among authors: moschke k.
Front Mol Neurosci. 2017 Jan 10;9:163. doi: 10.3389/fnmol.2016.00163. eCollection 2016.
Front Mol Neurosci. 2017.
PMID: 28119565
Free PMC article.
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Differential transgene expression patterns in Alzheimer mouse models revealed by novel human amyloid precursor protein-specific antibodies.
Höfling C, Morawski M, Zeitschel U, Zanier ER, Moschke K, Serdaroglu A, Canneva F, von Hörsten S, De Simoni MG, Forloni G, Jäger C, Kremmer E, Roßner S, Lichtenthaler SF, Kuhn PH.
Höfling C, et al. Among authors: moschke k.
Aging Cell. 2016 Oct;15(5):953-63. doi: 10.1111/acel.12508. Epub 2016 Jul 29.
Aging Cell. 2016.
PMID: 27470171
Free PMC article.
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BACE1 Inhibitor MK-8931 Alters Formation but Not Stability of Dendritic Spines.
Blume T, Filser S, Jaworska A, Blain JF, Koenig G, Moschke K, Lichtenthaler SF, Herms J.
Blume T, et al. Among authors: moschke k.
Front Aging Neurosci. 2018 Jul 26;10:229. doi: 10.3389/fnagi.2018.00229. eCollection 2018.
Front Aging Neurosci. 2018.
PMID: 30093858
Free PMC article.
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Discovery of a series of selective and cell permeable beta-secretase (BACE1) inhibitors by fragment linking with the assistance of STD-NMR.
Fang WS, Sun DY, Yang S, Cheng C, Moschke K, Li T, Sun S, Lichtenthaler SF, Huang J, Wang Y.
Fang WS, et al. Among authors: moschke k.
Bioorg Chem. 2019 Nov;92:103253. doi: 10.1016/j.bioorg.2019.103253. Epub 2019 Sep 13.
Bioorg Chem. 2019.
PMID: 31557620
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Extensive Structure Modification on Luteolin-Cinnamic Acid Conjugates Leading to BACE1 Inhibitors with Optimal Pharmacological Properties.
Sun DY, Cheng C, Moschke K, Huang J, Fang WS.
Sun DY, et al. Among authors: moschke k.
Molecules. 2019 Dec 26;25(1):102. doi: 10.3390/molecules25010102.
Molecules. 2019.
PMID: 31888099
Free PMC article.
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