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Identifying cis Elements for Spatiotemporal Control of Mammalian DNA Replication.
Sima J, Chakraborty A, Dileep V, Michalski M, Klein KN, Holcomb NP, Turner JL, Paulsen MT, Rivera-Mulia JC, Trevilla-Garcia C, Bartlett DA, Zhao PA, Washburn BK, Nora EP, Kraft K, Mundlos S, Bruneau BG, Ljungman M, Fraser P, Ay F, Gilbert DM. Sima J, et al. Among authors: mundlos s. Cell. 2019 Feb 7;176(4):816-830.e18. doi: 10.1016/j.cell.2018.11.036. Epub 2018 Dec 27. Cell. 2019. PMID: 30595451 Free PMC article.
Disruptions of topological chromatin domains cause pathogenic rewiring of gene-enhancer interactions.
Lupiáñez DG, Kraft K, Heinrich V, Krawitz P, Brancati F, Klopocki E, Horn D, Kayserili H, Opitz JM, Laxova R, Santos-Simarro F, Gilbert-Dussardier B, Wittler L, Borschiwer M, Haas SA, Osterwalder M, Franke M, Timmermann B, Hecht J, Spielmann M, Visel A, Mundlos S. Lupiáñez DG, et al. Among authors: mundlos s. Cell. 2015 May 21;161(5):1012-1025. doi: 10.1016/j.cell.2015.04.004. Epub 2015 May 7. Cell. 2015. PMID: 25959774 Free PMC article.
Formation of new chromatin domains determines pathogenicity of genomic duplications.
Franke M, Ibrahim DM, Andrey G, Schwarzer W, Heinrich V, Schöpflin R, Kraft K, Kempfer R, Jerković I, Chan WL, Spielmann M, Timmermann B, Wittler L, Kurth I, Cambiaso P, Zuffardi O, Houge G, Lambie L, Brancati F, Pombo A, Vingron M, Spitz F, Mundlos S. Franke M, et al. Among authors: mundlos s. Nature. 2016 Oct 13;538(7624):265-269. doi: 10.1038/nature19800. Epub 2016 Oct 5. Nature. 2016. PMID: 27706140
Serial genomic inversions induce tissue-specific architectural stripes, gene misexpression and congenital malformations.
Kraft K, Magg A, Heinrich V, Riemenschneider C, Schöpflin R, Markowski J, Ibrahim DM, Acuna-Hidalgo R, Despang A, Andrey G, Wittler L, Timmermann B, Vingron M, Mundlos S. Kraft K, et al. Among authors: mundlos s. Nat Cell Biol. 2019 Mar;21(3):305-310. doi: 10.1038/s41556-019-0273-x. Epub 2019 Feb 11. Nat Cell Biol. 2019. PMID: 30742094
Distal and proximal cis-regulatory elements sense X chromosome dosage and developmental state at the Xist locus.
Gjaltema RAF, Schwämmle T, Kautz P, Robson M, Schöpflin R, Ravid Lustig L, Brandenburg L, Dunkel I, Vechiatto C, Ntini E, Mutzel V, Schmiedel V, Marsico A, Mundlos S, Schulz EG. Gjaltema RAF, et al. Among authors: mundlos s. Mol Cell. 2022 Jan 6;82(1):190-208.e17. doi: 10.1016/j.molcel.2021.11.023. Epub 2021 Dec 20. Mol Cell. 2022. PMID: 34932975 Free article.
Polycomb-mediated genome architecture enables long-range spreading of H3K27 methylation.
Kraft K, Yost KE, Murphy SE, Magg A, Long Y, Corces MR, Granja JM, Wittler L, Mundlos S, Cech TR, Boettiger AN, Chang HY. Kraft K, et al. Among authors: mundlos s. Proc Natl Acad Sci U S A. 2022 May 31;119(22):e2201883119. doi: 10.1073/pnas.2201883119. Epub 2022 May 26. Proc Natl Acad Sci U S A. 2022. PMID: 35617427 Free PMC article.
397 results