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PLK1-inhibition can cause radiosensitization or radioresistance dependent on the treatment schedule.
Radiother Oncol. 2014 Feb;110(2):355-61. doi: 10.1016/j.radonc.2013.12.014. Epub 2014 Feb 4.
Radiother Oncol. 2014.
PMID: 24502970
The efficacy of CHK1 inhibitors is not altered by hypoxia, but is enhanced after reoxygenation.
Hasvold G, Nähse-Kumpf V, Tkacz-Stachowska K, Rofstad EK, Syljuåsen RG.
Hasvold G, et al. Among authors: nahse kumpf v.
Mol Cancer Ther. 2013 May;12(5):705-16. doi: 10.1158/1535-7163.MCT-12-0879. Epub 2013 May 1.
Mol Cancer Ther. 2013.
PMID: 23635654
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Cyclin-dependent kinase suppression by WEE1 kinase protects the genome through control of replication initiation and nucleotide consumption.
Beck H, Nähse-Kumpf V, Larsen MS, O'Hanlon KA, Patzke S, Holmberg C, Mejlvang J, Groth A, Nielsen O, Syljuåsen RG, Sørensen CS.
Beck H, et al. Among authors: nahse kumpf v.
Mol Cell Biol. 2012 Oct;32(20):4226-36. doi: 10.1128/MCB.00412-12. Epub 2012 Aug 20.
Mol Cell Biol. 2012.
PMID: 22907750
Free PMC article.
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A genetic screen identifies BRCA2 and PALB2 as key regulators of G2 checkpoint maintenance.
Menzel T, Nähse-Kumpf V, Kousholt AN, Klein DK, Lund-Andersen C, Lees M, Johansen JV, Syljuåsen RG, Sørensen CS.
Menzel T, et al. Among authors: nahse kumpf v.
EMBO Rep. 2011 Jul 1;12(7):705-12. doi: 10.1038/embor.2011.99.
EMBO Rep. 2011.
PMID: 21637299
Free PMC article.
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Combined inhibition of the cell cycle related proteins Wee1 and Chk1/2 induces synergistic anti-cancer effect in melanoma.
Magnussen GI, Emilsen E, Giller Fleten K, Engesæter B, Nähse-Kumpf V, Fjær R, Slipicevic A, Flørenes VA.
Magnussen GI, et al. Among authors: nahse kumpf v.
BMC Cancer. 2015 Jun 10;15:462. doi: 10.1186/s12885-015-1474-8.
BMC Cancer. 2015.
PMID: 26054341
Free PMC article.
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