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Serum Lipidomic Screen Identifies Key Metabolites, Pathways, and Disease Classifiers in Crohn's Disease.
Ferru-Clément R, Boucher G, Forest A, Bouchard B, Bitton A, Lesage S, Schumm P, Lazarev M, Brant S, Duerr RH, McGovern DPB, Silverberg M, Cho JH; NIDDK IBD Genetics Consortium, iGenoMed Consortium; Ananthakrishnan A, Xavier RJ, Rioux JD, Des Rosiers C. Ferru-Clément R, et al. Inflamm Bowel Dis. 2023 Jul 5;29(7):1024-1037. doi: 10.1093/ibd/izac281. Inflamm Bowel Dis. 2023. PMID: 36662167 Free PMC article.
BACKGROUND: There is an unmet medical need for biomarkers that capture host and environmental contributions in inflammatory bowel diseases (IBDs). This study aimed at testing the potential of circulating lipids as disease classifiers given their major roles in inflammation …
BACKGROUND: There is an unmet medical need for biomarkers that capture host and environmental contributions in inflammatory bowel disease …
Prostaglandins and calprotectin are genetically and functionally linked to the Inflammatory Bowel Diseases.
Karaky M, Boucher G, Mola S, Foisy S, Beauchamp C, Rivard ME, Burnette M, Gosselin H; iGenoMed Consortium; Bitton A, Charron G, Goyette P, Rioux JD. Karaky M, et al. PLoS Genet. 2022 Sep 26;18(9):e1010189. doi: 10.1371/journal.pgen.1010189. eCollection 2022 Sep. PLoS Genet. 2022. PMID: 36155972 Free PMC article.
BACKGROUND: Genome wide association studies (GWAS) have identified and validated more than 200 genomic loci associated with the inflammatory bowel disease (IBD), although for most the causal gene remains unknown. Given the importance of myeloid cells in IBD pathogen …
BACKGROUND: Genome wide association studies (GWAS) have identified and validated more than 200 genomic loci associated with the inflammatory …
Functional screen of inflammatory bowel disease genes reveals key epithelial functions.
Ntunzwenimana JC, Boucher G, Paquette J, Gosselin H, Alikashani A, Morin N, Beauchamp C, Thauvette L, Rivard MÈ, Dupuis F, Deschênes S, Foisy S, Latour F, Lavallée G, Daly MJ, Xavier RJ; iGenoMed Consortium; Charron G, Goyette P, Rioux JD. Ntunzwenimana JC, et al. Genome Med. 2021 Nov 11;13(1):181. doi: 10.1186/s13073-021-00996-7. Genome Med. 2021. PMID: 34758847 Free PMC article.
These analyses also identified two major clusters of genes: Cluster 1 contained the known IBD causal genes IFIH1, SBNO2, NFKB1, and NOD2, as well as genes from other IBD loci (ZFP36L1, IRF1, GIGYF1, OTUD3, AIRE and PITX1), whereas Cluster 2 contained the known causa …
These analyses also identified two major clusters of genes: Cluster 1 contained the known IBD causal genes IFIH1, SBNO2, NFKB1, and N …
Serum Analyte Profiles Associated With Crohn's Disease and Disease Location.
Boucher G, Paradis A, Chabot-Roy G, Coderre L, Hillhouse EE, Bitton A, Des Rosiers C, Levings MK, Schumm LP, Lazarev M, Brant SR, Duerr R, McGovern D, Silverberg MS, Cho J, Lesage S, Rioux JD; iGenoMed Consortium; NIDDK IBD Genetics Consortium. Boucher G, et al. Inflamm Bowel Dis. 2022 Jan 5;28(1):9-20. doi: 10.1093/ibd/izab123. Inflamm Bowel Dis. 2022. PMID: 34106269 Free PMC article.
BACKGROUND: Crohn's disease (CD) can affect any segment of the digestive tract but is most often localized in the ileal, ileocolonic, and colorectal regions of the intestines. ...Moreover, the identification of distinct profiles according to disease location supports the e …
BACKGROUND: Crohn's disease (CD) can affect any segment of the digestive tract but is most often localized in the ileal, ileocolonic, …
Comprehensive and Reproducible Untargeted Lipidomic Workflow Using LC-QTOF Validated for Human Plasma Analysis.
Forest A, Ruiz M, Bouchard B, Boucher G, Gingras O, Daneault C, Robillard Frayne I, Rhainds D; iGenoMed Consortium; NIDDK IBD Genetics Consortium; Tardif JC, Rioux JD, Des Rosiers C. Forest A, et al. J Proteome Res. 2018 Nov 2;17(11):3657-3670. doi: 10.1021/acs.jproteome.8b00270. Epub 2018 Oct 10. J Proteome Res. 2018. PMID: 30256116 Free PMC article.