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Fragile X protein mitigates TDP-43 toxicity by remodeling RNA granules and restoring translation.
Hum Mol Genet. 2015 Dec 15;24(24):6886-98. doi: 10.1093/hmg/ddv389. Epub 2015 Sep 18.
Hum Mol Genet. 2015.
PMID: 26385636
Free PMC article.
Ubiquilin-2 (UBQLN2) binds with high affinity to the C-terminal region of TDP-43 and modulates TDP-43 levels in H4 cells: characterization of inhibition by nucleic acids and 4-aminoquinolines.
Cassel JA, Reitz AB.
Cassel JA, et al.
Biochim Biophys Acta. 2013 Jun;1834(6):964-71. doi: 10.1016/j.bbapap.2013.03.020. Epub 2013 Mar 27.
Biochim Biophys Acta. 2013.
PMID: 23541532
Free PMC article.
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Characterization of a series of 4-aminoquinolines that stimulate caspase-7 mediated cleavage of TDP-43 and inhibit its function.
Cassel JA, McDonnell ME, Velvadapu V, Andrianov V, Reitz AB.
Cassel JA, et al.
Biochimie. 2012 Sep;94(9):1974-81. doi: 10.1016/j.biochi.2012.05.020. Epub 2012 May 29.
Biochimie. 2012.
PMID: 22659571
Free PMC article.
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Development of a novel nonradiometric assay for nucleic acid binding to TDP-43 suitable for high-throughput screening using AlphaScreen technology.
Cassel JA, Blass BE, Reitz AB, Pawlyk AC.
Cassel JA, et al.
J Biomol Screen. 2010 Oct;15(9):1099-106. doi: 10.1177/1087057110382778. Epub 2010 Sep 20.
J Biomol Screen. 2010.
PMID: 20855563
Free PMC article.
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