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Synthesis and structure-activity relationship studies of 4-((2-hydroxy-3-methoxybenzyl)amino)benzenesulfonamide derivatives as potent and selective inhibitors of 12-lipoxygenase.
Luci DK, Jameson JB 2nd, Yasgar A, Diaz G, Joshi N, Kantz A, Markham K, Perry S, Kuhn N, Yeung J, Kerns EH, Schultz L, Holinstat M, Nadler JL, Taylor-Fishwick DA, Jadhav A, Simeonov A, Holman TR, Maloney DJ. Luci DK, et al. Among authors: nadler jl. J Med Chem. 2014 Jan 23;57(2):495-506. doi: 10.1021/jm4016476. Epub 2014 Jan 6. J Med Chem. 2014. PMID: 24393039 Free PMC article.
Discovery of potent and selective inhibitors of human platelet-type 12- lipoxygenase.
Kenyon V, Rai G, Jadhav A, Schultz L, Armstrong M, Jameson JB 2nd, Perry S, Joshi N, Bougie JM, Leister W, Taylor-Fishwick DA, Nadler JL, Holinstat M, Simeonov A, Maloney DJ, Holman TR. Kenyon V, et al. Among authors: nadler jl. J Med Chem. 2011 Aug 11;54(15):5485-97. doi: 10.1021/jm2005089. Epub 2011 Jul 8. J Med Chem. 2011. PMID: 21739938 Free PMC article.
Minireview: 12-Lipoxygenase and Islet β-Cell Dysfunction in Diabetes.
Tersey SA, Bolanis E, Holman TR, Maloney DJ, Nadler JL, Mirmira RG. Tersey SA, et al. Among authors: nadler jl. Mol Endocrinol. 2015 Jun;29(6):791-800. doi: 10.1210/me.2015-1041. Epub 2015 Mar 24. Mol Endocrinol. 2015. PMID: 25803446 Free PMC article. Review.
Role of the 12-lipoxygenase pathway in diabetes pathogenesis and complications.
Dobrian AD, Morris MA, Taylor-Fishwick DA, Holman TR, Imai Y, Mirmira RG, Nadler JL. Dobrian AD, et al. Among authors: nadler jl. Pharmacol Ther. 2019 Mar;195:100-110. doi: 10.1016/j.pharmthera.2018.10.010. Epub 2018 Oct 19. Pharmacol Ther. 2019. PMID: 30347209 Free PMC article. Review.
Functional and pathological roles of the 12- and 15-lipoxygenases.
Dobrian AD, Lieb DC, Cole BK, Taylor-Fishwick DA, Chakrabarti SK, Nadler JL. Dobrian AD, et al. Among authors: nadler jl. Prog Lipid Res. 2011 Jan;50(1):115-31. doi: 10.1016/j.plipres.2010.10.005. Epub 2010 Oct 21. Prog Lipid Res. 2011. PMID: 20970452 Free PMC article. Review.
257 results