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The unique hypusine modification of eIF5A promotes islet beta cell inflammation and dysfunction in mice.
Maier B, Ogihara T, Trace AP, Tersey SA, Robbins RD, Chakrabarti SK, Nunemaker CS, Stull ND, Taylor CA, Thompson JE, Dondero RS, Lewis EC, Dinarello CA, Nadler JL, Mirmira RG. Maier B, et al. Among authors: nadler jl. J Clin Invest. 2010 Jun;120(6):2156-70. doi: 10.1172/JCI38924. Epub 2010 May 24. J Clin Invest. 2010. PMID: 20501948 Free PMC article.
Deletion of 12/15-lipoxygenase alters macrophage and islet function in NOD-Alox15(null) mice, leading to protection against type 1 diabetes development.
Green-Mitchell SM, Tersey SA, Cole BK, Ma K, Kuhn NS, Cunningham TD, Maybee NA, Chakrabarti SK, McDuffie M, Taylor-Fishwick DA, Mirmira RG, Nadler JL, Morris MA. Green-Mitchell SM, et al. Among authors: nadler jl. PLoS One. 2013;8(2):e56763. doi: 10.1371/journal.pone.0056763. Epub 2013 Feb 21. PLoS One. 2013. PMID: 23437231 Free PMC article.
Minireview: 12-Lipoxygenase and Islet β-Cell Dysfunction in Diabetes.
Tersey SA, Bolanis E, Holman TR, Maloney DJ, Nadler JL, Mirmira RG. Tersey SA, et al. Among authors: nadler jl. Mol Endocrinol. 2015 Jun;29(6):791-800. doi: 10.1210/me.2015-1041. Epub 2015 Mar 24. Mol Endocrinol. 2015. PMID: 25803446 Free PMC article. Review.
Inhibition of 12/15-Lipoxygenase Protects Against β-Cell Oxidative Stress and Glycemic Deterioration in Mouse Models of Type 1 Diabetes.
Hernandez-Perez M, Chopra G, Fine J, Conteh AM, Anderson RM, Linnemann AK, Benjamin C, Nelson JB, Benninger KS, Nadler JL, Maloney DJ, Tersey SA, Mirmira RG. Hernandez-Perez M, et al. Among authors: nadler jl. Diabetes. 2017 Nov;66(11):2875-2887. doi: 10.2337/db17-0215. Epub 2017 Aug 25. Diabetes. 2017. PMID: 28842399 Free PMC article.
257 results