Najjar SM - Search Results

1

Hyperinsulinemia drives hepatic insulin resistance in male mice with liver-specific Ceacam1 deletion independently of lipolysis.

Ghadieh HE, Russo L, Muturi HT, Ghanem SS, Manaserh IH, Noh HL, Suk S, Kim JK, Hill JW, Najjar SM. Ghadieh HE, et al. Among authors: najjar sm. Metabolism. 2019 Apr;93:33-43. doi: 10.1016/j.metabol.2019.01.008. Epub 2019 Jan 19. Metabolism. 2019. PMID: 30664851 Free PMC article.

2

Ceacam1 deletion causes vascular alterations in large vessels.

Najjar SM, Ledford KJ, Abdallah SL, Paus A, Russo L, Kaw MK, Ramakrishnan SK, Muturi HT, Raphael CK, Lester SG, Heinrich G, Pierre SV, Benndorf R, Kleff V, Jaffa AA, Lévy E, Vazquez G, Goldberg IJ, Beauchemin N, Scalia R, Ergün S. Najjar SM, et al. Am J Physiol Endocrinol Metab. 2013 Aug 15;305(4):E519-29. doi: 10.1152/ajpendo.00266.2013. Epub 2013 Jun 25. Am J Physiol Endocrinol Metab. 2013. PMID: 23800882 Free PMC article.

3

CEACAM1 loss links inflammation to insulin resistance in obesity and non-alcoholic steatohepatitis (NASH).

Najjar SM, Russo L. Najjar SM, et al. Semin Immunopathol. 2014 Jan;36(1):55-71. doi: 10.1007/s00281-013-0407-3. Epub 2013 Nov 21. Semin Immunopathol. 2014. PMID: 24258517 Free PMC article. Review.

4

High-fat diet amplifies renal renin angiotensin system expression, blood pressure elevation, and renal dysfunction caused by Ceacam1 null deletion.

Li C, Culver SA, Quadri S, Ledford KL, Al-Share QY, Ghadieh HE, Najjar SM, Siragy HM. Li C, et al. Among authors: najjar sm. Am J Physiol Endocrinol Metab. 2015 Nov 1;309(9):E802-10. doi: 10.1152/ajpendo.00158.2015. Epub 2015 Sep 15. Am J Physiol Endocrinol Metab. 2015. PMID: 26374765 Free PMC article.

5

Leptin Resistance Contributes to Obesity in Mice with Null Mutation of Carcinoembryonic Antigen-related Cell Adhesion Molecule 1.

Heinrich G, Russo L, Castaneda TR, Pfeiffer V, Ghadieh HE, Ghanem SS, Wu J, Faulkner LD, Ergün S, McInerney MF, Hill JW, Najjar SM. Heinrich G, et al. Among authors: najjar sm. J Biol Chem. 2016 May 20;291(21):11124-32. doi: 10.1074/jbc.M116.716431. Epub 2016 Mar 21. J Biol Chem. 2016. PMID: 27002145 Free PMC article.

6

Fenofibrate Decreases Insulin Clearance and Insulin Secretion to Maintain Insulin Sensitivity.

Ramakrishnan SK, Russo L, Ghanem SS, Patel PR, Oyarce AM, Heinrich G, Najjar SM. Ramakrishnan SK, et al. Among authors: najjar sm. J Biol Chem. 2016 Nov 11;291(46):23915-23924. doi: 10.1074/jbc.M116.745778. Epub 2016 Sep 23. J Biol Chem. 2016. PMID: 27662905 Free PMC article.

7

Role for hepatic CEACAM1 in regulating fatty acid metabolism along the adipocyte-hepatocyte axis.

Russo L, Ghadieh HE, Ghanem SS, Al-Share QY, Smiley ZN, Gatto-Weis C, Esakov EL, McInerney MF, Heinrich G, Tong X, Yin L, Najjar SM. Russo L, et al. Among authors: najjar sm. J Lipid Res. 2016 Dec;57(12):2163-2175. doi: 10.1194/jlr.M072066. Epub 2016 Oct 24. J Lipid Res. 2016. PMID: 27777319 Free PMC article.

8

Loss of Hepatic CEACAM1: A Unifying Mechanism Linking Insulin Resistance to Obesity and Non-Alcoholic Fatty Liver Disease.

Heinrich G, Ghadieh HE, Ghanem SS, Muturi HT, Rezaei K, Al-Share QY, Bowman TA, Zhang D, Garofalo RS, Yin L, Najjar SM. Heinrich G, et al. Among authors: najjar sm. Front Endocrinol (Lausanne). 2017 Jan 26;8:8. doi: 10.3389/fendo.2017.00008. eCollection 2017. Front Endocrinol (Lausanne). 2017. PMID: 28184213 Free PMC article. Review.

9

Age-dependent insulin resistance in male mice with null deletion of the carcinoembryonic antigen-related cell adhesion molecule 2 gene.

Ghanem SS, Muturi HT, DeAngelis AM, Hu J, Kulkarni RN, Heinrich G, Najjar SM. Ghanem SS, et al. Among authors: najjar sm. Diabetologia. 2017 Sep;60(9):1751-1760. doi: 10.1007/s00125-017-4307-2. Epub 2017 May 31. Diabetologia. 2017. PMID: 28567513 Free PMC article.

10

Liver-specific reconstitution of CEACAM1 reverses the metabolic abnormalities caused by its global deletion in male mice.

Russo L, Muturi HT, Ghadieh HE, Ghanem SS, Bowman TA, Noh HL, Dagdeviren S, Dogbey GY, Kim JK, Heinrich G, Najjar SM. Russo L, et al. Among authors: najjar sm. Diabetologia. 2017 Dec;60(12):2463-2474. doi: 10.1007/s00125-017-4432-y. Epub 2017 Sep 14. Diabetologia. 2017. PMID: 28913658 Free PMC article.

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