Narula G - Search Results

1

Small-Molecule Inhibitors Targeting Topoisomerase I as Novel Antituberculosis Agents.

Sandhaus S, Annamalai T, Welmaker G, Houghten RA, Paz C, Garcia PK, Andres A, Narula G, Rodrigues Felix C, Geden S, Netherton M, Gupta R, Rohde KH, Giulianotti MA, Tse-Dinh YC. Sandhaus S, et al. Among authors: narula g. Antimicrob Agents Chemother. 2016 Jun 20;60(7):4028-36. doi: 10.1128/AAC.00288-16. Print 2016 Jul. Antimicrob Agents Chemother. 2016. PMID: 27114277 Free PMC article.

2

Synthesis, evaluation, and CoMFA study of fluoroquinophenoxazine derivatives as bacterial topoisomerase IA inhibitors.

Yu X, Zhang M, Annamalai T, Bansod P, Narula G, Tse-Dinh YC, Sun D. Yu X, et al. Among authors: narula g. Eur J Med Chem. 2017 Jan 5;125:515-527. doi: 10.1016/j.ejmech.2016.09.053. Epub 2016 Sep 18. Eur J Med Chem. 2017. PMID: 27689733 Free PMC article.

3

The strictly conserved Arg-321 residue in the active site of Escherichia coli topoisomerase I plays a critical role in DNA rejoining.

Narula G, Annamalai T, Aedo S, Cheng B, Sorokin E, Wong A, Tse-Dinh YC. Narula G, et al. J Biol Chem. 2011 May 27;286(21):18673-80. doi: 10.1074/jbc.M111.229450. Epub 2011 Apr 7. J Biol Chem. 2011. PMID: 21478161 Free PMC article.

4

A surface plasmon resonance study of the intermolecular interaction between Escherichia coli topoisomerase I and pBAD/Thio supercoiled plasmid DNA.

Tiwari PB, Annamalai T, Cheng B, Narula G, Wang X, Tse-Dinh YC, He J, Darici Y. Tiwari PB, et al. Among authors: narula g. Biochem Biophys Res Commun. 2014 Mar 7;445(2):445-50. doi: 10.1016/j.bbrc.2014.02.015. Epub 2014 Feb 12. Biochem Biophys Res Commun. 2014. PMID: 24530905 Free PMC article.

5

The DNA relaxation activity and covalent complex accumulation of Mycobacterium tuberculosis topoisomerase I can be assayed in Escherichia coli: application for identification of potential FRET-dye labeling sites.

Narula G, Becker J, Cheng B, Dani N, Abrenica MV, Tse-Dinh YC. Narula G, et al. BMC Biochem. 2010 Sep 30;11:41. doi: 10.1186/1471-2091-11-41. BMC Biochem. 2010. PMID: 20920291 Free PMC article.

6

Residues of E. coli topoisomerase I conserved for interaction with a specific cytosine base to facilitate DNA cleavage.

Narula G, Tse-Dinh YC. Narula G, et al. Nucleic Acids Res. 2012 Oct;40(18):9233-43. doi: 10.1093/nar/gks688. Epub 2012 Jul 24. Nucleic Acids Res. 2012. PMID: 22833607 Free PMC article.

7

Synthesis, structure-activity relationship studies, and antibacterial evaluation of 4-chromanones and chalcones, as well as olympicin A and derivatives.

Feng L, Maddox MM, Alam MZ, Tsutsumi LS, Narula G, Bruhn DF, Wu X, Sandhaus S, Lee RB, Simmons CJ, Tse-Dinh YC, Hurdle JG, Lee RE, Sun D. Feng L, et al. Among authors: narula g. J Med Chem. 2014 Oct 23;57(20):8398-420. doi: 10.1021/jm500853v. Epub 2014 Oct 7. J Med Chem. 2014. PMID: 25238443 Free PMC article.

8

Efficient Synthesis of Benzothiazinone Analogues with Activity against Intracellular Mycobacterium tuberculosis.

Richter A, Narula G, Rudolph I, Seidel RW, Wagner C, Av-Gay Y, Imming P. Richter A, et al. Among authors: narula g. ChemMedChem. 2022 Mar 18;17(6):e202100733. doi: 10.1002/cmdc.202100733. Epub 2021 Dec 23. ChemMedChem. 2022. PMID: 34939744 Free PMC article.

9

MymA Bioactivated Thioalkylbenzoxazole Prodrug Family Active against Mycobacterium tuberculosis.

Moure AL, Narula G, Sorrentino F, Bojang A, Tsui CKM, Sao Emani C, Porras-De Francisco E, Díaz B, Rebollo-López MJ, Torres-Gómez PA, López-Román EM, Camino I, Casado Castro P, Guijarro López L, Ortega F, Ballell L, Barros-Aguirre D, Remuiñán Blanco M, Av-Gay Y. Moure AL, et al. Among authors: narula g. J Med Chem. 2020 May 14;63(9):4732-4748. doi: 10.1021/acs.jmedchem.0c00003. Epub 2020 Apr 19. J Med Chem. 2020. PMID: 32275415

10

Protein tyrosine kinase, PtkA, is required for Mycobacterium tuberculosis growth in macrophages.

Wong D, Li W, Chao JD, Zhou P, Narula G, Tsui C, Ko M, Xie J, Martinez-Frailes C, Av-Gay Y. Wong D, et al. Among authors: narula g. Sci Rep. 2018 Jan 9;8(1):155. doi: 10.1038/s41598-017-18547-9. Sci Rep. 2018. PMID: 29317718 Free PMC article.

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