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Furoxans (Oxadiazole-4 N-oxides) with Attenuated Reactivity are Neuroprotective, Cross the Blood Brain Barrier, and Improve Passive Avoidance Memory.
Horton A, Nash K, Tackie-Yarboi E, Kostrevski A, Novak A, Raghavan A, Tulsulkar J, Alhadidi Q, Wamer N, Langenderfer B, Royster K, Ducharme M, Hagood K, Post M, Shah ZA, Schiefer IT. Horton A, et al. J Med Chem. 2018 May 24;61(10):4593-4607. doi: 10.1021/acs.jmedchem.8b00389. Epub 2018 May 7. J Med Chem. 2018. PMID: 29683322 Free PMC article.
Correction to Furoxans (Oxadiazole- N-oxides) with Attenuated Reactivity Are Neuroprotective, Cross the Blood Brain Barrier, and Improve Passive Avoidance Memory.
Horton A, Nash K, Tackie-Yarboi E, Kostrevski A, Novak A, Raghavan A, Tulsulkar J, Alhadidi Q, Wamer N, Langenderfer B, Royster K, Ducharme M, Hagood K, Post M, Shah ZA, Schiefer IT. Horton A, et al. J Med Chem. 2018 Jul 12;61(13):5773. doi: 10.1021/acs.jmedchem.8b00891. Epub 2018 Jun 21. J Med Chem. 2018. PMID: 29927599 No abstract available.
Discovery of highly potent, selective, and brain-penetrant aminopyrazole leucine-rich repeat kinase 2 (LRRK2) small molecule inhibitors.
Estrada AA, Chan BK, Baker-Glenn C, Beresford A, Burdick DJ, Chambers M, Chen H, Dominguez SL, Dotson J, Drummond J, Flagella M, Fuji R, Gill A, Halladay J, Harris SF, Heffron TP, Kleinheinz T, Lee DW, Le Pichon CE, Liu X, Lyssikatos JP, Medhurst AD, Moffat JG, Nash K, Scearce-Levie K, Sheng Z, Shore DG, Wong S, Zhang S, Zhang X, Zhu H, Sweeney ZK. Estrada AA, et al. J Med Chem. 2014 Feb 13;57(3):921-36. doi: 10.1021/jm401654j. Epub 2014 Jan 15. J Med Chem. 2014. PMID: 24354345
Discovery of highly potent, selective, and brain-penetrable leucine-rich repeat kinase 2 (LRRK2) small molecule inhibitors.
Estrada AA, Liu X, Baker-Glenn C, Beresford A, Burdick DJ, Chambers M, Chan BK, Chen H, Ding X, DiPasquale AG, Dominguez SL, Dotson J, Drummond J, Flagella M, Flynn S, Fuji R, Gill A, Gunzner-Toste J, Harris SF, Heffron TP, Kleinheinz T, Lee DW, Le Pichon CE, Lyssikatos JP, Medhurst AD, Moffat JG, Mukund S, Nash K, Scearce-Levie K, Sheng Z, Shore DG, Tran T, Trivedi N, Wang S, Zhang S, Zhang X, Zhao G, Zhu H, Sweeney ZK. Estrada AA, et al. J Med Chem. 2012 Nov 26;55(22):9416-33. doi: 10.1021/jm301020q. Epub 2012 Oct 15. J Med Chem. 2012. PMID: 22985112
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