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Page 1
Diversity of variant alleles encoding Kidd, Duffy, and Kell antigens in individuals with sickle cell disease using whole genome sequencing data from the NHLBI TOPMed Program.
Dinardo CL, Oliveira TGM, Kelly S, Ashley-Koch A, Telen M, Schmidt LC, Castilho S, Melo K, Dezan MR, Wheeler MM, Johnsen JM, Nickerson DA, Jain D, Custer B, Pereira AC, Sabino EC; NHLBI Recipient Epidemiology Donor Evaluation Study (REDS-III) International Component-Brazil, the Outcome Modifying Genes in SCD (OMG) study and the NHLBI Trans-Omics for Precision Medicine (TOPMed) Program Sickle Cell Disease Working Group. Dinardo CL, et al. Transfusion. 2021 Feb;61(2):603-616. doi: 10.1111/trf.16204. Epub 2020 Nov 24. Transfusion. 2021. PMID: 33231305
STUDY DESIGN AND METHODS: Two large SCD cohorts were studied: the Recipient Epidemiology and Donor Evaluation Study III (REDS-III) (n = 2634) and the Outcome Modifying Gene in SCD (OMG) (n = 640). Most of the studied individ …
STUDY DESIGN AND METHODS: Two large SCD cohorts were studied: the Recipient Epidemiology and Donor Evaluation …
Piloting and implementation of quality assessment and quality control procedures in RBC-Omics: a large multi-center study of red blood cell hemolysis during storage.
Stone M, Keating SM, Kanias T, Lanteri MC, Lebedeva M, Sinchar D, Hampton D, Jakub A, Rychka V, Brewer G, Bakkour S, Gefter N, Murcia K, Page GP, Endres-Dighe S, Bialkowski W, Fu X, Zimring J, Raife TJ, Kleinman S, Gladwin MT, Busch MP; National Heart, Lung, and Blood Institute Recipient Epidemiology Donor Evaluation Study III (REDS-III) Program. Stone M, et al. Transfusion. 2019 Jan;59(1):57-66. doi: 10.1111/trf.15099. Epub 2018 Dec 19. Transfusion. 2019. PMID: 30566231
BACKGROUND: The major aims of the RBC-Omics study were to evaluate the genomic and metabolomic determinants of spontaneous and stress-induced hemolysis during RBC storage. This study was unique in scale and design to allow evaluation of RBC donations from a sufficie …
BACKGROUND: The major aims of the RBC-Omics study were to evaluate the genomic and metabolomic determinants of spontaneous and stress …
Elevated risk for iron depletion in high-school age blood donors.
Spencer BR, Bialkowski W, Creel DV, Cable RG, Kiss JE, Stone M, McClure C, Kleinman S, Glynn SA, Mast AE; National Heart, Lung, and Blood Institute Recipient Epidemiology and Donor Evaluation Study-III (REDS-III) Program. Spencer BR, et al. Transfusion. 2019 May;59(5):1706-1716. doi: 10.1111/trf.15133. Epub 2019 Jan 11. Transfusion. 2019. PMID: 30633813 Free PMC article.
Successful, age-eligible donors were enrolled from high school blood drives at two large US blood centers. ...CONCLUSION: Age 16 to 18 years-old is an independent risk factor for iron deficiency in blood donors at any donation frequency. Bloo …
Successful, age-eligible donors were enrolled from high school blood drives at two large US blood centers. ...CONCLUSIO …
Multiple-ancestry genome-wide association study identifies 27 loci associated with measures of hemolysis following blood storage.
Page GP, Kanias T, Guo YJ, Lanteri MC, Zhang X, Mast AE, Cable RG, Spencer BR, Kiss JE, Fang F, Endres-Dighe SM, Brambilla D, Nouraie M, Gordeuk VR, Kleinman S, Busch MP, Gladwin MT; National Heart, Lung, and Blood Institute (NHLBI) Recipient Epidemiology Donor Evaluation Study–III (REDS-III) program. Page GP, et al. J Clin Invest. 2021 Jul 1;131(13):e146077. doi: 10.1172/JCI146077. J Clin Invest. 2021. PMID: 34014839 Free PMC article.
BackgroundThe evolutionary pressure of endemic malaria and other erythrocytic pathogens has shaped variation in genes encoding erythrocyte structural and functional proteins, influencing responses to hemolytic stress during transfusion and disease.MethodsWe sought to identify suc …
BackgroundThe evolutionary pressure of endemic malaria and other erythrocytic pathogens has shaped variation in genes encoding erythrocyte s …
Slower response to treatment of iron-deficiency anaemia in pregnant women infected with HIV: a prospective cohort study.
Hull JC, Bloch EM, Ingram C, Crookes R, Vaughan J, Courtney L, Jauregui A, Hilton JF, Murphy EL; REDS-III South Africa Program. Hull JC, et al. BJOG. 2021 Sep;128(10):1674-1681. doi: 10.1111/1471-0528.16671. Epub 2021 Mar 16. BJOG. 2021. PMID: 33587784 Free PMC article.
Earlier effective management of iron deficiency could reduce the incidence of peripartum blood transfusion. TWEETABLE ABSTRACT: Among pregnant women with iron-deficiency anaemia in South Africa, HIV slows haemoglobin recovery in response to oral iron therapy....
Earlier effective management of iron deficiency could reduce the incidence of peripartum blood transfusion. TWEETABLE ABSTRACT: Among …