Normant E - Search Results

1

Carboxypeptidase E is a regulated secretory pathway sorting receptor: genetic obliteration leads to endocrine disorders in Cpe(fat) mice.

Cool DR, Normant E, Shen F, Chen HC, Pannell L, Zhang Y, Loh YP. Cool DR, et al. Among authors: normant e. Cell. 1997 Jan 10;88(1):73-83. doi: 10.1016/s0092-8674(00)81860-7. Cell. 1997. PMID: 9019408 Free article.

2

Depletion of carboxypeptidase E, a regulated secretory pathway sorting receptor, causes misrouting and constitutive secretion of proinsulin and proenkephalin, but not chromogranin A.

Normant E, Loh YP. Normant E, et al. Endocrinology. 1998 Apr;139(4):2137-45. doi: 10.1210/endo.139.4.5951. Endocrinology. 1998. PMID: 9529003

3

Oligomerization of pro-opiomelanocortin is independent of pH, calcium and the sorting signal for the regulated secretory pathway.

Cawley NX, Normant E, Chen A, Loh YP. Cawley NX, et al. Among authors: normant e. FEBS Lett. 2000 Sep 8;481(1):37-41. doi: 10.1016/s0014-5793(00)01961-x. FEBS Lett. 2000. PMID: 10984611 Free article.

4

Development of 17-allylamino-17-demethoxygeldanamycin hydroquinone hydrochloride (IPI-504), an anti-cancer agent directed against Hsp90.

Sydor JR, Normant E, Pien CS, Porter JR, Ge J, Grenier L, Pak RH, Ali JA, Dembski MS, Hudak J, Patterson J, Penders C, Pink M, Read MA, Sang J, Woodward C, Zhang Y, Grayzel DS, Wright J, Barrett JA, Palombella VJ, Adams J, Tong JK. Sydor JR, et al. Among authors: normant e. Proc Natl Acad Sci U S A. 2006 Nov 14;103(46):17408-13. doi: 10.1073/pnas.0608372103. Epub 2006 Nov 7. Proc Natl Acad Sci U S A. 2006. PMID: 17090671 Free PMC article.

5

Design, synthesis, and biological evaluation of hydroquinone derivatives of 17-amino-17-demethoxygeldanamycin as potent, water-soluble inhibitors of Hsp90.

Ge J, Normant E, Porter JR, Ali JA, Dembski MS, Gao Y, Georges AT, Grenier L, Pak RH, Patterson J, Sydor JR, Tibbitts TT, Tong JK, Adams J, Palombella VJ. Ge J, et al. Among authors: normant e. J Med Chem. 2006 Jul 27;49(15):4606-15. doi: 10.1021/jm0603116. J Med Chem. 2006. PMID: 16854066

6

IPI-504, a novel and soluble HSP-90 inhibitor, blocks the unfolded protein response in multiple myeloma cells.

Patterson J, Palombella VJ, Fritz C, Normant E. Patterson J, et al. Among authors: normant e. Cancer Chemother Pharmacol. 2008 May;61(6):923-32. doi: 10.1007/s00280-007-0546-0. Epub 2007 Jul 12. Cancer Chemother Pharmacol. 2008. PMID: 17624530

7

Ansamycin inhibitors of Hsp90: nature's prototype for anti-chaperone therapy.

Porter JR, Ge J, Lee J, Normant E, West K. Porter JR, et al. Among authors: normant e. Curr Top Med Chem. 2009;9(15):1386-418. doi: 10.2174/156802609789895719. Curr Top Med Chem. 2009. PMID: 19860734 Review.

8

The antiproliferative activity of the heat shock protein 90 inhibitor IPI-504 is not dependent on NAD(P)H:quinone oxidoreductase 1 activity in vivo.

Douglas M, Lim AR, Porter JR, West K, Pink MM, Ge J, Wylie AA, Tibbits TT, Biggs K, Curtis M, Palombella VJ, Adams J, Fritz CC, Normant E. Douglas M, et al. Among authors: normant e. Mol Cancer Ther. 2009 Dec;8(12):3369-78. doi: 10.1158/1535-7163.MCT-09-0568. Mol Cancer Ther. 2009. PMID: 19952119

9

Hsp90 (heat shock protein 90) inhibitor occupancy is a direct determinant of client protein degradation and tumor growth arrest in vivo.

Tillotson B, Slocum K, Coco J, Whitebread N, Thomas B, West KA, MacDougall J, Ge J, Ali JA, Palombella VJ, Normant E, Adams J, Fritz CC. Tillotson B, et al. Among authors: normant e. J Biol Chem. 2010 Dec 17;285(51):39835-43. doi: 10.1074/jbc.M110.141580. Epub 2010 Oct 12. J Biol Chem. 2010. PMID: 20940293 Free PMC article.

10

The Hsp90 inhibitor IPI-504 rapidly lowers EML4-ALK levels and induces tumor regression in ALK-driven NSCLC models.

Normant E, Paez G, West KA, Lim AR, Slocum KL, Tunkey C, McDougall J, Wylie AA, Robison K, Caliri K, Palombella VJ, Fritz CC. Normant E, et al. Oncogene. 2011 Jun 2;30(22):2581-6. doi: 10.1038/onc.2010.625. Epub 2011 Jan 24. Oncogene. 2011. PMID: 21258415

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