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The genomic basis of mood instability: identification of 46 loci in 363,705 UK Biobank participants, genetic correlation with psychiatric disorders, and association with gene expression and function.
Ward J, Tunbridge EM, Sandor C, Lyall LM, Ferguson A, Strawbridge RJ, Lyall DM, Cullen B, Graham N, Johnston KJA, Webber C, Escott-Price V, O'Donovan M, Pell JP, Bailey MES, Harrison PJ, Smith DJ. Ward J, et al. Mol Psychiatry. 2020 Nov;25(11):3091-3099. doi: 10.1038/s41380-019-0439-8. Epub 2019 Jun 5. Mol Psychiatry. 2020. PMID: 31168069 Free PMC article.
Schizophrenia: a genetic disorder of the synapse?
Owen MJ, O'Donovan MC, Harrison PJ. Owen MJ, et al. BMJ. 2005 Jan 22;330(7484):158-9. doi: 10.1136/bmj.330.7484.158. BMJ. 2005. PMID: 15661762 Free PMC article. No abstract available.
Bipolar disorder and polymorphisms in the dysbindin gene (DTNBP1).
Raybould R, Green EK, MacGregor S, Gordon-Smith K, Heron J, Hyde S, Caesar S, Nikolov I, Williams N, Jones L, O'Donovan MC, Owen MJ, Jones I, Kirov G, Craddock N. Raybould R, et al. Biol Psychiatry. 2005 Apr 1;57(7):696-701. doi: 10.1016/j.biopsych.2005.01.018. Biol Psychiatry. 2005. PMID: 15820225
Variation at the DAOA/G30 locus influences susceptibility to major mood episodes but not psychosis in schizophrenia and bipolar disorder.
Williams NM, Green EK, Macgregor S, Dwyer S, Norton N, Williams H, Raybould R, Grozeva D, Hamshere M, Zammit S, Jones L, Cardno A, Kirov G, Jones I, O'Donovan MC, Owen MJ, Craddock N. Williams NM, et al. Arch Gen Psychiatry. 2006 Apr;63(4):366-73. doi: 10.1001/archpsyc.63.4.366. Arch Gen Psychiatry. 2006. PMID: 16585465
Identification of loci associated with schizophrenia by genome-wide association and follow-up.
O'Donovan MC, Craddock N, Norton N, Williams H, Peirce T, Moskvina V, Nikolov I, Hamshere M, Carroll L, Georgieva L, Dwyer S, Holmans P, Marchini JL, Spencer CC, Howie B, Leung HT, Hartmann AM, Möller HJ, Morris DW, Shi Y, Feng G, Hoffmann P, Propping P, Vasilescu C, Maier W, Rietschel M, Zammit S, Schumacher J, Quinn EM, Schulze TG, Williams NM, Giegling I, Iwata N, Ikeda M, Darvasi A, Shifman S, He L, Duan J, Sanders AR, Levinson DF, Gejman PV, Cichon S, Nöthen MM, Gill M, Corvin A, Rujescu D, Kirov G, Owen MJ, Buccola NG, Mowry BJ, Freedman R, Amin F, Black DW, Silverman JM, Byerley WF, Cloninger CR; Molecular Genetics of Schizophrenia Collaboration. O'Donovan MC, et al. Nat Genet. 2008 Sep;40(9):1053-5. doi: 10.1038/ng.201. Nat Genet. 2008. PMID: 18677311
Identification of novel candidate genes for treatment response to risperidone and susceptibility for schizophrenia: integrated analysis among pharmacogenomics, mouse expression, and genetic case-control association approaches.
Ikeda M, Tomita Y, Mouri A, Koga M, Okochi T, Yoshimura R, Yamanouchi Y, Kinoshita Y, Hashimoto R, Williams HJ, Takeda M, Nakamura J, Nabeshima T, Owen MJ, O'Donovan MC, Honda H, Arinami T, Ozaki N, Iwata N. Ikeda M, et al. Biol Psychiatry. 2010 Feb 1;67(3):263-9. doi: 10.1016/j.biopsych.2009.08.030. Epub 2009 Oct 22. Biol Psychiatry. 2010. PMID: 19850283 Clinical Trial.
Psychosis susceptibility gene ZNF804A and cognitive performance in schizophrenia.
Walters JT, Corvin A, Owen MJ, Williams H, Dragovic M, Quinn EM, Judge R, Smith DJ, Norton N, Giegling I, Hartmann AM, Möller HJ, Muglia P, Moskvina V, Dwyer S, O'Donoghue T, Morar B, Cooper M, Chandler D, Jablensky A, Gill M, Kaladjieva L, Morris DW, O'Donovan MC, Rujescu D, Donohoe G. Walters JT, et al. Arch Gen Psychiatry. 2010 Jul;67(7):692-700. doi: 10.1001/archgenpsychiatry.2010.81. Arch Gen Psychiatry. 2010. PMID: 20603450
Genome-wide association study of schizophrenia in a Japanese population.
Ikeda M, Aleksic B, Kinoshita Y, Okochi T, Kawashima K, Kushima I, Ito Y, Nakamura Y, Kishi T, Okumura T, Fukuo Y, Williams HJ, Hamshere ML, Ivanov D, Inada T, Suzuki M, Hashimoto R, Ujike H, Takeda M, Craddock N, Kaibuchi K, Owen MJ, Ozaki N, O'Donovan MC, Iwata N. Ikeda M, et al. Biol Psychiatry. 2011 Mar 1;69(5):472-8. doi: 10.1016/j.biopsych.2010.07.010. Epub 2010 Sep 15. Biol Psychiatry. 2011. PMID: 20832056
GWA study data mining and independent replication identify cardiomyopathy-associated 5 (CMYA5) as a risk gene for schizophrenia.
Chen X, Lee G, Maher BS, Fanous AH, Chen J, Zhao Z, Guo A, van den Oord E, Sullivan PF, Shi J, Levinson DF, Gejman PV, Sanders A, Duan J, Owen MJ, Craddock NJ, O'Donovan MC, Blackman J, Lewis D, Kirov GK, Qin W, Schwab S, Wildenauer D, Chowdari K, Nimgaonkar V, Straub RE, Weinberger DR, O'Neill FA, Walsh D, Bronstein M, Darvasi A, Lencz T, Malhotra AK, Rujescu D, Giegling I, Werge T, Hansen T, Ingason A, Nöethen MM, Rietschel M, Cichon S, Djurovic S, Andreassen OA, Cantor RM, Ophoff R, Corvin A, Morris DW, Gill M, Pato CN, Pato MT, Macedo A, Gurling HM, McQuillin A, Pimm J, Hultman C, Lichtenstein P, Sklar P, Purcell SM, Scolnick E, St Clair D, Blackwood DH, Kendler KS; GROUP investigators; International Schizophrenia Consortium. Chen X, et al. Mol Psychiatry. 2011 Nov;16(11):1117-29. doi: 10.1038/mp.2010.96. Epub 2010 Sep 14. Mol Psychiatry. 2011. PMID: 20838396 Free PMC article.
1,279 results