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Page 1
Substituted imidazoles as glucagon receptor antagonists.
Chang LL, Sidler KL, Cascieri MA, de Laszlo S, Koch G, Li B, MacCoss M, Mantlo N, O'Keefe S, Pang M, Rolando A, Hagmann WK. Chang LL, et al. Bioorg Med Chem Lett. 2001 Sep 17;11(18):2549-53. doi: 10.1016/s0960-894x(01)00498-x. Bioorg Med Chem Lett. 2001. PMID: 11549467
Pyrroles and other heterocycles as inhibitors of p38 kinase.
de Laszlo SE, Visco D, Agarwal L, Chang L, Chin J, Croft G, Forsyth A, Fletcher D, Frantz B, Hacker C, Hanlon W, Harper C, Kostura M, Li B, Luell S, MacCoss M, Mantlo N, O'Neill EA, Orevillo C, Pang M, Parsons J, Rolando A, Sahly Y, Sidler K, O'Keefe SJ, et al. de Laszlo SE, et al. Bioorg Med Chem Lett. 1998 Oct 6;8(19):2689-94. doi: 10.1016/s0960-894x(98)00495-8. Bioorg Med Chem Lett. 1998. PMID: 9873604
Pyridazine based inhibitors of p38 MAPK.
McIntyre CJ, Ponticello GS, Liverton NJ, O'Keefe SJ, O'Neill EA, Pang M, Schwartz CD, Claremon DA. McIntyre CJ, et al. Bioorg Med Chem Lett. 2002 Feb 25;12(4):689-92. doi: 10.1016/s0960-894x(01)00834-4. Bioorg Med Chem Lett. 2002. PMID: 11844702
Molecular basis for p38 protein kinase inhibitor specificity.
Lisnock J, Tebben A, Frantz B, O'Neill EA, Croft G, O'Keefe SJ, Li B, Hacker C, de Laszlo S, Smith A, Libby B, Liverton N, Hermes J, LoGrasso P. Lisnock J, et al. Biochemistry. 1998 Nov 24;37(47):16573-81. doi: 10.1021/bi981591x. Biochemistry. 1998. PMID: 9843424
Kinetic mechanism for p38 MAP kinase.
LoGrasso PV, Frantz B, Rolando AM, O'Keefe SJ, Hermes JD, O'Neill EA. LoGrasso PV, et al. Biochemistry. 1997 Aug 26;36(34):10422-7. doi: 10.1021/bi9706778. Biochemistry. 1997. PMID: 9265622
p38MAP kinase inhibitors. Part 1: design and development of a new class of potent and highly selective inhibitors based on 3,4-dihydropyrido[3,2-d]pyrimidone scaffold.
Natarajan SR, Wisnoski DD, Singh SB, Stelmach JE, O'Neill EA, Schwartz CD, Thompson CM, Fitzgerald CE, O'Keefe SJ, Kumar S, Hop CE, Zaller DM, Schmatz DM, Doherty JB. Natarajan SR, et al. Bioorg Med Chem Lett. 2003 Jan 20;13(2):273-6. doi: 10.1016/s0960-894x(02)00876-4. Bioorg Med Chem Lett. 2003. PMID: 12482438
SAR of 3,4-dihydropyrido[3,2-d]pyrimidone p38 inhibitors.
Liu L, Stelmach JE, Natarajan SR, Chen MH, Singh SB, Schwartz CD, Fitzgerald CE, O'Keefe SJ, Zaller DM, Schmatz DM, Doherty JB. Liu L, et al. Bioorg Med Chem Lett. 2003 Nov 17;13(22):3979-82. doi: 10.1016/j.bmcl.2003.08.059. Bioorg Med Chem Lett. 2003. PMID: 14592489
475 results