O'Rahilly S - Search Results

1

Genetic Predisposition to an Impaired Metabolism of the Branched-Chain Amino Acids and Risk of Type 2 Diabetes: A Mendelian Randomisation Analysis.

Lotta LA, Scott RA, Sharp SJ, Burgess S, Luan J, Tillin T, Schmidt AF, Imamura F, Stewart ID, Perry JR, Marney L, Koulman A, Karoly ED, Forouhi NG, Sjögren RJ, Näslund E, Zierath JR, Krook A, Savage DB, Griffin JL, Chaturvedi N, Hingorani AD, Khaw KT, Barroso I, McCarthy MI, O'Rahilly S, Wareham NJ, Langenberg C. Lotta LA, et al. PLoS Med. 2016 Nov 29;13(11):e1002179. doi: 10.1371/journal.pmed.1002179. eCollection 2016 Nov. PLoS Med. 2016. PMID: 27898682 Free PMC article.

2

Evidence for linkage of stature to chromosome 3p26 in a large U.K. Family data set ascertained for type 2 diabetes.

Wiltshire S, Frayling TM, Hattersley AT, Hitman GA, Walker M, Levy JC, O'Rahilly S, Groves CJ, Menzel S, Cardon LR, McCarthy MI. Wiltshire S, et al. Am J Hum Genet. 2002 Feb;70(2):543-6. doi: 10.1086/338760. Epub 2001 Dec 20. Am J Hum Genet. 2002. PMID: 11753821 Free PMC article.

3

Association and haplotype analysis of the insulin-degrading enzyme (IDE) gene, a strong positional and biological candidate for type 2 diabetes susceptibility.

Groves CJ, Wiltshire S, Smedley D, Owen KR, Frayling TM, Walker M, Hitman GA, Levy JC, O'Rahilly S, Menzel S, Hattersley AT, McCarthy MI. Groves CJ, et al. Diabetes. 2003 May;52(5):1300-5. doi: 10.2337/diabetes.52.5.1300. Diabetes. 2003. PMID: 12716770

4

Rosiglitazone increases indexes of stearoyl-CoA desaturase activity in humans: link to insulin sensitization and the role of dominant-negative mutation in peroxisome proliferator-activated receptor-gamma.

Risérus U, Tan GD, Fielding BA, Neville MJ, Currie J, Savage DB, Chatterjee VK, Frayn KN, O'Rahilly S, Karpe F. Risérus U, et al. Diabetes. 2005 May;54(5):1379-84. doi: 10.2337/diabetes.54.5.1379. Diabetes. 2005. PMID: 15855323 Clinical Trial.

5

Transcript and metabolite analysis of the effects of tamoxifen in rat liver reveals inhibition of fatty acid synthesis in the presence of hepatic steatosis.

Lelliott CJ, López M, Curtis RK, Parker N, Laudes M, Yeo G, Jimenez-Liñan M, Grosse J, Saha AK, Wiggins D, Hauton D, Brand MD, O'Rahilly S, Griffin JL, Gibbons GF, Vidal-Puig A. Lelliott CJ, et al. FASEB J. 2005 Jul;19(9):1108-19. doi: 10.1096/fj.04-3196com. FASEB J. 2005. PMID: 15985534

6

Sequence variants in the melatonin-related receptor gene (GPR50) associate with circulating triglyceride and HDL levels.

Bhattacharyya S, Luan J, Challis B, Keogh J, Montague C, Brennand J, Morten J, Lowenbeim S, Jenkins S, Farooqi IS, Wareham NJ, O'Rahilly S. Bhattacharyya S, et al. J Lipid Res. 2006 Apr;47(4):761-6. doi: 10.1194/jlr.M500338-JLR200. Epub 2006 Jan 25. J Lipid Res. 2006. PMID: 16436372 Free article.

7

Significant linkage of BMI to chromosome 10p in the U.K. population and evaluation of GAD2 as a positional candidate.

Groves CJ, Zeggini E, Walker M, Hitman GA, Levy JC, O'Rahilly S, Hattersley AT, McCarthy MI, Wiltshire S. Groves CJ, et al. Diabetes. 2006 Jun;55(6):1884-9. doi: 10.2337/db05-1674. Diabetes. 2006. PMID: 16731858

8

Genetic variants and common diseases--better late than never.

O'Rahilly S, Wareham NJ. O'Rahilly S, et al. N Engl J Med. 2006 Jul 20;355(3):306-8. doi: 10.1056/NEJMe068140. N Engl J Med. 2006. PMID: 16855272 No abstract available.

9

Non-DNA binding, dominant-negative, human PPARgamma mutations cause lipodystrophic insulin resistance.

Agostini M, Schoenmakers E, Mitchell C, Szatmari I, Savage D, Smith A, Rajanayagam O, Semple R, Luan J, Bath L, Zalin A, Labib M, Kumar S, Simpson H, Blom D, Marais D, Schwabe J, Barroso I, Trembath R, Wareham N, Nagy L, Gurnell M, O'Rahilly S, Chatterjee K. Agostini M, et al. Cell Metab. 2006 Oct;4(4):303-11. doi: 10.1016/j.cmet.2006.09.003. Cell Metab. 2006. PMID: 17011503 Free PMC article.

10

Comment on "A common genetic variant is associated with adult and childhood obesity".

Loos RJ, Barroso I, O'rahilly S, Wareham NJ. Loos RJ, et al. Science. 2007 Jan 12;315(5809):187; author reply 187. doi: 10.1126/science.1130012. Science. 2007. PMID: 17218509 Free PMC article.

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