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Genetic studies of urinary metabolites illuminate mechanisms of detoxification and excretion in humans.
Schlosser P, Li Y, Sekula P, Raffler J, Grundner-Culemann F, Pietzner M, Cheng Y, Wuttke M, Steinbrenner I, Schultheiss UT, Kotsis F, Kacprowski T, Forer L, Hausknecht B, Ekici AB, Nauck M, Völker U; GCKD Investigators; Walz G, Oefner PJ, Kronenberg F, Mohney RP, Köttgen M, Suhre K, Eckardt KU, Kastenmüller G, Köttgen A. Schlosser P, et al. Among authors: oefner pj. Nat Genet. 2020 Feb;52(2):167-176. doi: 10.1038/s41588-019-0567-8. Epub 2020 Jan 20. Nat Genet. 2020. PMID: 31959995 Free PMC article.
Genome-Wide Association Studies of Metabolites in Patients with CKD Identify Multiple Loci and Illuminate Tubular Transport Mechanisms.
Li Y, Sekula P, Wuttke M, Wahrheit J, Hausknecht B, Schultheiss UT, Gronwald W, Schlosser P, Tucci S, Ekici AB, Spiekerkoetter U, Kronenberg F, Eckardt KU, Oefner PJ, Köttgen A; GCKD Investigators. Li Y, et al. Among authors: oefner pj. J Am Soc Nephrol. 2018 May;29(5):1513-1524. doi: 10.1681/ASN.2017101099. Epub 2018 Mar 15. J Am Soc Nephrol. 2018. PMID: 29545352 Free PMC article.
A Metabolome-Wide Association Study of Kidney Function and Disease in the General Population.
Sekula P, Goek ON, Quaye L, Barrios C, Levey AS, Römisch-Margl W, Menni C, Yet I, Gieger C, Inker LA, Adamski J, Gronwald W, Illig T, Dettmer K, Krumsiek J, Oefner PJ, Valdes AM, Meisinger C, Coresh J, Spector TD, Mohney RP, Suhre K, Kastenmüller G, Köttgen A. Sekula P, et al. Among authors: oefner pj. J Am Soc Nephrol. 2016 Apr;27(4):1175-88. doi: 10.1681/ASN.2014111099. Epub 2015 Oct 8. J Am Soc Nephrol. 2016. PMID: 26449609 Free PMC article.
A multi-source data integration approach reveals novel associations between metabolites and renal outcomes in the German Chronic Kidney Disease study.
Altenbuchinger M, Zacharias HU, Solbrig S, Schäfer A, Büyüközkan M, Schultheiß UT, Kotsis F, Köttgen A, Spang R, Oefner PJ, Krumsiek J, Gronwald W. Altenbuchinger M, et al. Among authors: oefner pj. Sci Rep. 2019 Sep 27;9(1):13954. doi: 10.1038/s41598-019-50346-2. Sci Rep. 2019. PMID: 31562371 Free PMC article.
Urine Metabolite Levels, Adverse Kidney Outcomes, and Mortality in CKD Patients: A Metabolome-wide Association Study.
Steinbrenner I, Schultheiss UT, Kotsis F, Schlosser P, Stockmann H, Mohney RP, Schmid M, Oefner PJ, Eckardt KU, Köttgen A, Sekula P; German Chronic Kidney Disease Investigators. Steinbrenner I, et al. Among authors: oefner pj. Am J Kidney Dis. 2021 Nov;78(5):669-677.e1. doi: 10.1053/j.ajkd.2021.01.018. Epub 2021 Apr 9. Am J Kidney Dis. 2021. PMID: 33839201
A Predictive Model for Progression of CKD to Kidney Failure Based on Routine Laboratory Tests.
Zacharias HU, Altenbuchinger M, Schultheiss UT, Raffler J, Kotsis F, Ghasemi S, Ali I, Kollerits B, Metzger M, Steinbrenner I, Sekula P, Massy ZA, Combe C, Kalra PA, Kronenberg F, Stengel B, Eckardt KU, Köttgen A, Schmid M, Gronwald W, Oefner PJ; GCKD Investigators. Zacharias HU, et al. Among authors: oefner pj. Am J Kidney Dis. 2022 Feb;79(2):217-230.e1. doi: 10.1053/j.ajkd.2021.05.018. Epub 2021 Jul 20. Am J Kidney Dis. 2022. PMID: 34298143
Author Correction: Rare genetic variants affecting urine metabolite levels link population variation to inborn errors of metabolism.
Cheng Y, Schlosser P, Hertel J, Sekula P, Oefner PJ, Spiekerkoetter U, Mielke J, Freitag DF, Schmidts M; GCKD Investigators; Kronenberg F, Eckardt KU, Thiele I, Li Y, Köttgen A. Cheng Y, et al. Among authors: oefner pj. Nat Commun. 2021 Oct 6;12(1):5938. doi: 10.1038/s41467-021-26242-7. Nat Commun. 2021. PMID: 34615878 Free PMC article. No abstract available.
309 results