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Interpreting type 1 diabetes risk with genetics and single-cell epigenomics.
Chiou J, Geusz RJ, Okino ML, Han JY, Miller M, Melton R, Beebe E, Benaglio P, Huang S, Korgaonkar K, Heller S, Kleger A, Preissl S, Gorkin DU, Sander M, Gaulton KJ. Chiou J, et al. Among authors: okino ml. Nature. 2021 Jun;594(7863):398-402. doi: 10.1038/s41586-021-03552-w. Epub 2021 May 19. Nature. 2021. PMID: 34012112 Free PMC article.
Pancreatic islet chromatin accessibility and conformation reveals distal enhancer networks of type 2 diabetes risk.
Greenwald WW, Chiou J, Yan J, Qiu Y, Dai N, Wang A, Nariai N, Aylward A, Han JY, Kadakia N, Regue L, Okino ML, Drees F, Kramer D, Vinckier N, Minichiello L, Gorkin D, Avruch J, Frazer KA, Sander M, Ren B, Gaulton KJ. Greenwald WW, et al. Among authors: okino ml. Nat Commun. 2019 May 7;10(1):2078. doi: 10.1038/s41467-019-09975-4. Nat Commun. 2019. PMID: 31064983 Free PMC article.
Single-cell chromatin accessibility identifies pancreatic islet cell type- and state-specific regulatory programs of diabetes risk.
Chiou J, Zeng C, Cheng Z, Han JY, Schlichting M, Miller M, Mendez R, Huang S, Wang J, Sui Y, Deogaygay A, Okino ML, Qiu Y, Sun Y, Kudtarkar P, Fang R, Preissl S, Sander M, Gorkin DU, Gaulton KJ. Chiou J, et al. Among authors: okino ml. Nat Genet. 2021 Apr;53(4):455-466. doi: 10.1038/s41588-021-00823-0. Epub 2021 Apr 1. Nat Genet. 2021. PMID: 33795864 Free PMC article.
Type 1 diabetes risk genes mediate pancreatic beta cell survival in response to proinflammatory cytokines.
Benaglio P, Zhu H, Okino ML, Yan J, Elgamal R, Nariai N, Beebe E, Korgaonkar K, Qiu Y, Donovan MKR, Chiou J, Wang G, Newsome J, Kaur J, Miller M, Preissl S, Corban S, Aylward A, Taipale J, Ren B, Frazer KA, Sander M, Gaulton KJ. Benaglio P, et al. Among authors: okino ml. Cell Genom. 2022 Nov 11;2(12):100214. doi: 10.1016/j.xgen.2022.100214. eCollection 2022 Dec 14. Cell Genom. 2022. PMID: 36778047 Free PMC article.
Integrating genetics with single-cell multiomic measurements across disease states identifies mechanisms of beta cell dysfunction in type 2 diabetes.
Wang G, Chiou J, Zeng C, Miller M, Matta I, Han JY, Kadakia N, Okino ML, Beebe E, Mallick M, Camunas-Soler J, Dos Santos T, Dai XQ, Ellis C, Hang Y, Kim SK, MacDonald PE, Kandeel FR, Preissl S, Gaulton KJ, Sander M. Wang G, et al. Among authors: okino ml. Nat Genet. 2023 Jun;55(6):984-994. doi: 10.1038/s41588-023-01397-9. Epub 2023 May 25. Nat Genet. 2023. PMID: 37231096 Free PMC article.
Mapping genetic effects on cell type-specific chromatin accessibility and annotating complex immune trait variants using single nucleus ATAC-seq in peripheral blood.
Benaglio P, Newsome J, Han JY, Chiou J, Aylward A, Corban S, Miller M, Okino ML, Kaur J, Preissl S, Gorkin DU, Gaulton KJ. Benaglio P, et al. Among authors: okino ml. PLoS Genet. 2023 Jun 8;19(6):e1010759. doi: 10.1371/journal.pgen.1010759. eCollection 2023 Jun. PLoS Genet. 2023. PMID: 37289818 Free PMC article.
An integrated map of cell type-specific gene expression in pancreatic islets.
Elgamal RM, Kudtarkar P, Melton RL, Mummey HM, Benaglio P, Okino ML, Gaulton KJ. Elgamal RM, et al. Among authors: okino ml. bioRxiv [Preprint]. 2023 Feb 4:2023.02.03.526994. doi: 10.1101/2023.02.03.526994. bioRxiv. 2023. PMID: 36778506 Free PMC article. Updated. Preprint.
11 results