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Neil3-dependent base excision repair regulates lipid metabolism and prevents atherosclerosis in Apoe-deficient mice.
Skarpengland T, Holm S, Scheffler K, Gregersen I, Dahl TB, Suganthan R, Segers FM, Østlie I, Otten JJ, Luna L, Ketelhuth DF, Lundberg AM, Neurauter CG, Hildrestrand G, Skjelland M, Bjørndal B, Svardal AM, Iversen PO, Hedin U, Nygård S, Olstad OK, Krohg-Sørensen K, Slupphaug G, Eide L, Kuśnierczyk A, Folkersen L, Ueland T, Berge RK, Hansson GK, Biessen EA, Halvorsen B, Bjørås M, Aukrust P. Skarpengland T, et al. Among authors: otten jj. Sci Rep. 2016 Jun 22;6:28337. doi: 10.1038/srep28337. Sci Rep. 2016. PMID: 27328939 Free PMC article.
Genetic and pharmacological modifications of thrombin formation in apolipoprotein e-deficient mice determine atherosclerosis severity and atherothrombosis onset in a neutrophil-dependent manner.
Borissoff JI, Otten JJ, Heeneman S, Leenders P, van Oerle R, Soehnlein O, Loubele ST, Hamulyák K, Hackeng TM, Daemen MJ, Degen JL, Weiler H, Esmon CT, van Ryn J, Biessen EA, Spronk HM, ten Cate H. Borissoff JI, et al. Among authors: otten jj. PLoS One. 2013;8(2):e55784. doi: 10.1371/journal.pone.0055784. Epub 2013 Feb 7. PLoS One. 2013. PMID: 23409043 Free PMC article.
Leukocyte Overexpression of Intracellular NAMPT Attenuates Atherosclerosis by Regulating PPARγ-Dependent Monocyte Differentiation and Function.
Bermudez B, Dahl TB, Medina I, Groeneweg M, Holm S, Montserrat-de la Paz S, Rousch M, Otten J, Herias V, Varela LM, Ranheim T, Yndestad A, Ortega-Gomez A, Abia R, Nagy L, Aukrust P, Muriana FJG, Halvorsen B, Biessen EAL. Bermudez B, et al. Arterioscler Thromb Vasc Biol. 2017 Jun;37(6):1157-1167. doi: 10.1161/ATVBAHA.116.308187. Epub 2017 Apr 13. Arterioscler Thromb Vasc Biol. 2017. PMID: 28408371
In situ lipid-loading activates peripheral dendritic cell subsets characterized by cellular ROS accumulation but compromises their capacity to prime naïve T cells.
Christ A, Maas SL, Jin H, Lu C, Legein B, Wijnands E, Temmerman L, Otten J, Isaacs A, Zenke M, Stoll M, Biessen EAL, van der Vorst EPC. Christ A, et al. Free Radic Biol Med. 2024 Jan;210:406-415. doi: 10.1016/j.freeradbiomed.2023.11.044. Epub 2023 Dec 5. Free Radic Biol Med. 2024. PMID: 38061606 Free article.
Identification of a gene network driving the attenuated response to lipopolysaccharide of monocytes from hypertensive coronary artery disease patients.
Lu C, Donners MMPC, de Baaij JBJ, Jin H, Otten JJT, Manca M, van Zonneveld AJ, Jukema JW, Kraaijeveld A, Kuiper J, Pasterkamp G, Mees B, Sluimer JC, Cavill R, Karel JMH, Goossens P, Biessen EAL. Lu C, et al. Among authors: otten jjt. Front Immunol. 2024 Feb 12;15:1286382. doi: 10.3389/fimmu.2024.1286382. eCollection 2024. Front Immunol. 2024. PMID: 38410507 Free PMC article.
51 results