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Experimental evolution, genetic analysis and genome re-sequencing reveal the mutation conferring artemisinin resistance in an isogenic lineage of malaria parasites.
Hunt P, Martinelli A, Modrzynska K, Borges S, Creasey A, Rodrigues L, Beraldi D, Loewe L, Fawcett R, Kumar S, Thomson M, Trivedi U, Otto TD, Pain A, Blaxter M, Cravo P. Hunt P, et al. Among authors: otto td. BMC Genomics. 2010 Sep 16;11:499. doi: 10.1186/1471-2164-11-499. BMC Genomics. 2010. PMID: 20846421 Free PMC article.
Chromosome and gene copy number variation allow major structural change between species and strains of Leishmania.
Rogers MB, Hilley JD, Dickens NJ, Wilkes J, Bates PA, Depledge DP, Harris D, Her Y, Herzyk P, Imamura H, Otto TD, Sanders M, Seeger K, Dujardin JC, Berriman M, Smith DF, Hertz-Fowler C, Mottram JC. Rogers MB, et al. Among authors: otto td. Genome Res. 2011 Dec;21(12):2129-42. doi: 10.1101/gr.122945.111. Epub 2011 Oct 28. Genome Res. 2011. PMID: 22038252 Free PMC article.
Optimal enzymes for amplifying sequencing libraries.
Quail MA, Otto TD, Gu Y, Harris SR, Skelly TF, McQuillan JA, Swerdlow HP, Oyola SO. Quail MA, et al. Among authors: otto td. Nat Methods. 2011 Dec 28;9(1):10-1. doi: 10.1038/nmeth.1814. Nat Methods. 2011. PMID: 22205512 No abstract available.
A systematically improved high quality genome and transcriptome of the human blood fluke Schistosoma mansoni.
Protasio AV, Tsai IJ, Babbage A, Nichol S, Hunt M, Aslett MA, De Silva N, Velarde GS, Anderson TJ, Clark RC, Davidson C, Dillon GP, Holroyd NE, LoVerde PT, Lloyd C, McQuillan J, Oliveira G, Otto TD, Parker-Manuel SJ, Quail MA, Wilson RA, Zerlotini A, Dunne DW, Berriman M. Protasio AV, et al. Among authors: otto td. PLoS Negl Trop Dis. 2012 Jan;6(1):e1455. doi: 10.1371/journal.pntd.0001455. Epub 2012 Jan 10. PLoS Negl Trop Dis. 2012. PMID: 22253936 Free PMC article.
Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.
Jackson AP, Berry A, Aslett M, Allison HC, Burton P, Vavrova-Anderson J, Brown R, Browne H, Corton N, Hauser H, Gamble J, Gilderthorp R, Marcello L, McQuillan J, Otto TD, Quail MA, Sanders MJ, van Tonder A, Ginger ML, Field MC, Barry JD, Hertz-Fowler C, Berriman M. Jackson AP, et al. Among authors: otto td. Proc Natl Acad Sci U S A. 2012 Feb 28;109(9):3416-21. doi: 10.1073/pnas.1117313109. Epub 2012 Feb 13. Proc Natl Acad Sci U S A. 2012. PMID: 22331916 Free PMC article.
150 results