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Conservative versus liberal oxygenation targets in critically ill children (Oxy-PICU): a UK multicentre, open, parallel-group, randomised clinical trial.
Peters MJ, Gould DW, Ray S, Thomas K, Chang I, Orzol M, O'Neill L, Agbeko R, Au C, Draper E, Elliot-Major L, Giallongo E, Jones GAL, Lampro L, Lillie J, Pappachan J, Peters S, Ramnarayan P, Sadique Z, Rowan KM, Harrison DA, Mouncey PR; Oxy-PICU Investigators of the Paediatric Critical Care Society Study Group (PCCS-SG). Peters MJ, et al. Lancet. 2024 Jan 27;403(10424):355-364. doi: 10.1016/S0140-6736(23)01968-2. Epub 2023 Dec 1. Lancet. 2024. PMID: 38048787 Free article. Clinical Trial.
We aimed to evaluate whether conservative oxygenation would reduce duration of organ support or incidence of death compared to standard care. METHODS: Oxy-PICU was a pragmatic, multicentre, open-label, randomised controlled trial in 15 UK paediatric intensive care u …
We aimed to evaluate whether conservative oxygenation would reduce duration of organ support or incidence of death compared to standard care …
Randomization to a Liberal Versus Conservative Oxygenation Target: Redox Responses in Critically Ill Children.
Jones GAL, Eaton S, Orford M, Ray S, Wiley D, Ramnarayan P, Inwald D, Grocott MPW, Griksaitis M, Pappachan J, O'Neill L, Mouncey PR, Harrison DA, Rowan KM, Peters MJ; Oxy-PICU Investigators of the Paediatric Critical Care Society Study Group (PCCS-SG). Jones GAL, et al. Pediatr Crit Care Med. 2023 Mar 1;24(3):e137-e146. doi: 10.1097/PCC.0000000000003175. Epub 2023 Jan 19. Pediatr Crit Care Med. 2023. PMID: 36728001 Clinical Trial.
DESIGN: Mechanistic substudy nested within the Oxygen in PICU (Oxy-PICU) pilot randomized feasibility clinical trial ( ClinicalTrials.gov : NCT03040570). SETTING: Three U.K. mixed medical and surgical PICUs in university hospitals. PATIENTS: Seventy-five eligible pa …
DESIGN: Mechanistic substudy nested within the Oxygen in PICU (Oxy-PICU) pilot randomized feasibility clinical trial ( Clinica …