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A Class of Diacylglycerol Acyltransferase 1 Inhibitors Identified by a Combination of Phenotypic High-throughput Screening, Genomics, and Genetics.
Tschapalda K, Zhang YQ, Liu L, Golovnina K, Schlemper T, Eichmann TO, Lal-Nag M, Sreenivasan U, McLenithan J, Ziegler S, Sztalryd C, Lass A, Auld D, Oliver B, Waldmann H, Li Z, Shen M, Boxer MB, Beller M. Tschapalda K, et al. EBioMedicine. 2016 Jun;8:49-59. doi: 10.1016/j.ebiom.2016.04.014. Epub 2016 Apr 16. EBioMedicine. 2016. PMID: 27428418 Free PMC article.
Monoglyceride lipase deficiency modulates endocannabinoid signaling and improves plaque stability in ApoE-knockout mice.
Vujic N, Schlager S, Eichmann TO, Madreiter-Sokolowski CT, Goeritzer M, Rainer S, Schauer S, Rosenberger A, Woelfler A, Doddapattar P, Zimmermann R, Hoefler G, Lass A, Graier WF, Radovic B, Kratky D. Vujic N, et al. Atherosclerosis. 2016 Jan;244:9-21. doi: 10.1016/j.atherosclerosis.2015.10.109. Epub 2015 Nov 2. Atherosclerosis. 2016. PMID: 26584135 Free PMC article.
ATGL and CGI-58 are lipid droplet proteins of the hepatic stellate cell line HSC-T6.
Eichmann TO, Grumet L, Taschler U, Hartler J, Heier C, Woblistin A, Pajed L, Kollroser M, Rechberger G, Thallinger GG, Zechner R, Haemmerle G, Zimmermann R, Lass A. Eichmann TO, et al. J Lipid Res. 2015 Oct;56(10):1972-84. doi: 10.1194/jlr.M062372. Epub 2015 Aug 31. J Lipid Res. 2015. PMID: 26330055 Free PMC article.
Adipose triglyceride lipase acts on neutrophil lipid droplets to regulate substrate availability for lipid mediator synthesis.
Schlager S, Goeritzer M, Jandl K, Frei R, Vujic N, Kolb D, Strohmaier H, Dorow J, Eichmann TO, Rosenberger A, Wölfler A, Lass A, Kershaw EE, Ceglarek U, Dichlberger A, Heinemann A, Kratky D. Schlager S, et al. J Leukoc Biol. 2015 Nov;98(5):837-50. doi: 10.1189/jlb.3A0515-206R. Epub 2015 Jun 24. J Leukoc Biol. 2015. PMID: 26109679 Free PMC article.
17 results