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Targeting the trypanosome kinetochore with CLK1 protein kinase inhibitors.
Saldivia M, Fang E, Ma X, Myburgh E, Carnielli JBT, Bower-Lepts C, Brown E, Ritchie R, Lakshminarayana SB, Chen YL, Patra D, Ornelas E, Koh HXY, Williams SL, Supek F, Paape D, McCulloch R, Kaiser M, Barrett MP, Jiricek J, Diagana TT, Mottram JC, Rao SPS. Saldivia M, et al. Among authors: paape d. Nat Microbiol. 2020 Oct;5(10):1207-1216. doi: 10.1038/s41564-020-0745-6. Epub 2020 Jul 13. Nat Microbiol. 2020. PMID: 32661312 Free PMC article.
Positively selected modifications in the pore of TbAQP2 allow pentamidine to enter Trypanosoma brucei.
Alghamdi AH, Munday JC, Campagnaro GD, Gurvic D, Svensson F, Okpara CE, Kumar A, Quintana J, Martin Abril ME, Milić P, Watson L, Paape D, Settimo L, Dimitriou A, Wielinska J, Smart G, Anderson LF, Woodley CM, Kelly SPY, Ibrahim HM, Hulpia F, Al-Salabi MI, Eze AA, Sprenger T, Teka IA, Gudin S, Weyand S, Field M, Dardonville C, Tidwell RR, Carrington M, O'Neill P, Boykin DW, Zachariae U, De Koning HP. Alghamdi AH, et al. Among authors: paape d. Elife. 2020 Aug 11;9:e56416. doi: 10.7554/eLife.56416. Elife. 2020. PMID: 32762841 Free PMC article.
Veterinary trypanocidal benzoxaboroles are peptidase-activated prodrugs.
Giordani F, Paape D, Vincent IM, Pountain AW, Fernández-Cortés F, Rico E, Zhang N, Morrison LJ, Freund Y, Witty MJ, Peter R, Edwards DY, Wilkes JM, van der Hooft JJJ, Regnault C, Read KD, Horn D, Field MC, Barrett MP. Giordani F, et al. Among authors: paape d. PLoS Pathog. 2020 Nov 3;16(11):e1008932. doi: 10.1371/journal.ppat.1008932. eCollection 2020 Nov. PLoS Pathog. 2020. PMID: 33141865 Free PMC article.
Cloning and functional complementation of ten Schistosoma mansoni phosphodiesterases expressed in the mammalian host stages.
Munday JC, Kunz S, Kalejaiye TD, Siderius M, Schroeder S, Paape D, Alghamdi AH, Abbasi Z, Huang SX, Donachie AM, William S, Sabra AN, Sterk GJ, Botros SS, Brown DG, Hoffman CS, Leurs R, de Koning HP. Munday JC, et al. Among authors: paape d. PLoS Negl Trop Dis. 2020 Jul 30;14(7):e0008447. doi: 10.1371/journal.pntd.0008447. eCollection 2020 Jul. PLoS Negl Trop Dis. 2020. PMID: 32730343 Free PMC article.
34 results