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The chaperone HSPB8 reduces the accumulation of truncated TDP-43 species in cells and protects against TDP-43-mediated toxicity.
Crippa V, Cicardi ME, Ramesh N, Seguin SJ, Ganassi M, Bigi I, Diacci C, Zelotti E, Baratashvili M, Gregory JM, Dobson CM, Cereda C, Pandey UB, Poletti A, Carra S. Crippa V, et al. Among authors: pandey ub. Hum Mol Genet. 2016 Sep 15;25(18):3908-3924. doi: 10.1093/hmg/ddw232. Epub 2016 Jul 27. Hum Mol Genet. 2016. PMID: 27466192 Free PMC article.
RNA-binding ability of FUS regulates neurodegeneration, cytoplasmic mislocalization and incorporation into stress granules associated with FUS carrying ALS-linked mutations.
Daigle JG, Lanson NA Jr, Smith RB, Casci I, Maltare A, Monaghan J, Nichols CD, Kryndushkin D, Shewmaker F, Pandey UB. Daigle JG, et al. Among authors: pandey ub. Hum Mol Genet. 2013 Mar 15;22(6):1193-205. doi: 10.1093/hmg/dds526. Epub 2012 Dec 20. Hum Mol Genet. 2013. PMID: 23257289 Free PMC article.
A fruitful endeavor: modeling ALS in the fruit fly.
Casci I, Pandey UB. Casci I, et al. Among authors: pandey ub. Brain Res. 2015 May 14;1607:47-74. doi: 10.1016/j.brainres.2014.09.064. Epub 2014 Oct 5. Brain Res. 2015. PMID: 25289585 Free PMC article. Review.
Pur-alpha regulates cytoplasmic stress granule dynamics and ameliorates FUS toxicity.
Daigle JG, Krishnamurthy K, Ramesh N, Casci I, Monaghan J, McAvoy K, Godfrey EW, Daniel DC, Johnson EM, Monahan Z, Shewmaker F, Pasinelli P, Pandey UB. Daigle JG, et al. Among authors: pandey ub. Acta Neuropathol. 2016 Apr;131(4):605-20. doi: 10.1007/s00401-015-1530-0. Epub 2016 Jan 4. Acta Neuropathol. 2016. PMID: 26728149 Free PMC article.
Mutations in TGM6 induce the unfolded protein response in SCA35.
Tripathy D, Vignoli B, Ramesh N, Polanco MJ, Coutelier M, Stephen CD, Canossa M, Monin ML, Aeschlimann P, Turberville S, Aeschlimann D, Schmahmann JD, Hadjivassiliou M, Durr A, Pandey UB, Pennuto M, Basso M. Tripathy D, et al. Among authors: pandey ub. Hum Mol Genet. 2017 Oct 1;26(19):3749-3762. doi: 10.1093/hmg/ddx259. Hum Mol Genet. 2017. PMID: 28934387
Isogenic FUS-eGFP iPSC Reporter Lines Enable Quantification of FUS Stress Granule Pathology that Is Rescued by Drugs Inducing Autophagy.
Marrone L, Poser I, Casci I, Japtok J, Reinhardt P, Janosch A, Andree C, Lee HO, Moebius C, Koerner E, Reinhardt L, Cicardi ME, Hackmann K, Klink B, Poletti A, Alberti S, Bickle M, Hermann A, Pandey UB, Hyman AA, Sterneckert JL. Marrone L, et al. Among authors: pandey ub. Stem Cell Reports. 2018 Feb 13;10(2):375-389. doi: 10.1016/j.stemcr.2017.12.018. Epub 2018 Jan 18. Stem Cell Reports. 2018. PMID: 29358088 Free PMC article.
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