Parsons WH - Search Results

1

Discovery of 3-piperidinyl-1-cyclopentanecarboxamide as a novel scaffold for highly potent CC chemokine receptor 2 antagonists.

Yang L, Butora G, Jiao RX, Pasternak A, Zhou C, Parsons WH, Mills SG, Vicario PP, Ayala JM, Cascieri MA, MacCoss M. Yang L, et al. Among authors: parsons wh. J Med Chem. 2007 May 31;50(11):2609-11. doi: 10.1021/jm070166b. Epub 2007 Apr 27. J Med Chem. 2007. PMID: 17461566

2

Novel, orally bioavailable gamma-aminoamide CC chemokine receptor 2 (CCR2) antagonists.

Pasternak A, Marino D, Vicario PP, Ayala JM, Cascierri MA, Parsons W, Mills SG, Maccoss M, Yang L. Pasternak A, et al. J Med Chem. 2006 Aug 10;49(16):4801-4. doi: 10.1021/jm060439n. J Med Chem. 2006. PMID: 16884289

3

Discovery of 3,5-bis(trifluoromethyl)benzyl L-arylglycinamide based potent CCR2 antagonists.

Yang L, Zhou C, Guo L, Morriello G, Butora G, Pasternak A, Parsons WH, Mills SG, MacCoss M, Vicario PP, Zweerink H, Ayala JM, Goyal S, Hanlon WA, Cascieri MA, Springer MS. Yang L, et al. Among authors: parsons wh. Bioorg Med Chem Lett. 2006 Jul 15;16(14):3735-9. doi: 10.1016/j.bmcl.2006.04.045. Epub 2006 May 15. Bioorg Med Chem Lett. 2006. PMID: 16698264

4

4-Amino-2-alkyl-butyramides as small molecule CCR2 antagonists with favorable pharmacokinetic properties.

Butora G, Morriello GJ, Kothandaraman S, Guiadeen D, Pasternak A, Parsons WH, MacCoss M, Vicario PP, Cascieri MA, Yang L. Butora G, et al. Among authors: parsons wh. Bioorg Med Chem Lett. 2006 Sep 15;16(18):4715-22. doi: 10.1016/j.bmcl.2006.07.011. Epub 2006 Jul 25. Bioorg Med Chem Lett. 2006. PMID: 16870431

5

Alpha-aminothiazole-gamma-aminobutanoic amides as potent, small molecule CCR2 receptor antagonists.

Zhou C, Guo L, Parsons WH, Mills SG, MacCoss M, Vicario PP, Zweerink H, Cascieri MA, Springer MS, Yang L. Zhou C, et al. Among authors: parsons wh. Bioorg Med Chem Lett. 2007 Jan 15;17(2):309-14. doi: 10.1016/j.bmcl.2006.10.059. Epub 2006 Oct 25. Bioorg Med Chem Lett. 2007. PMID: 17092717

6

3-Amino-1-alkyl-cyclopentane carboxamides as small molecule antagonists of the human and murine CC chemokine receptor 2.

Butora G, Jiao R, Parsons WH, Vicario PP, Jin H, Ayala JM, Cascieri MA, Yang L. Butora G, et al. Among authors: parsons wh. Bioorg Med Chem Lett. 2007 Jul 1;17(13):3636-41. doi: 10.1016/j.bmcl.2007.04.053. Epub 2007 Apr 25. Bioorg Med Chem Lett. 2007. PMID: 17482462

7

Cholecystokinin antagonists. Synthesis and biological evaluation of 3-substituted benzolactams.

Parsons WH, Patchett AA, Holloway MK, Smith GM, Davidson JL, Lotti VJ, Chang RS. Parsons WH, et al. J Med Chem. 1989 Aug;32(8):1681-5. doi: 10.1021/jm00128a004. J Med Chem. 1989. PMID: 2754692

8

Development, synthesis, and biological evaluation of (-)-trans-(2S,5S)-2-[3-[(2-oxopropyl)sulfonyl]-4-n-propoxy-5-(3- hydroxypropoxy)-phenyl]-5-(3,4,5-trimethoxyphenyl)tetrahydrofuran, a potent orally active platelet-activating factor (PAF) antagonist and its water-soluble prodrug phosphate ester.

Girotra NN, Biftu T, Ponpipom MM, Acton JJ, Alberts AW, Bach TN, Ball RG, Bugianesi RL, Parsons WH, Chabala JC, et al. Girotra NN, et al. Among authors: parsons wh. J Med Chem. 1992 Sep 18;35(19):3474-82. doi: 10.1021/jm00097a005. J Med Chem. 1992. PMID: 1404229

9

Synthesis and SAR of 1,2-trans-(1-hydroxy-3-phenylprop-1-yl)cyclopentane carboxamide derivatives, a new class of sodium channel blockers.

Ok D, Li C, Abbadie C, Felix JP, Fisher MH, Garcia ML, Kaczorowski GJ, Lyons KA, Martin WJ, Priest BT, Smith MM, Williams BS, Wyvratt MJ, Parsons WH. Ok D, et al. Among authors: parsons wh. Bioorg Med Chem Lett. 2006 Mar 1;16(5):1358-61. doi: 10.1016/j.bmcl.2005.11.051. Epub 2005 Dec 5. Bioorg Med Chem Lett. 2006. PMID: 16337121

10

Design and synthesis of P2-P1'-linked macrocyclic human renin inhibitors.

Weber AE, Halgren TA, Doyle JJ, Lynch RJ, Siegl PK, Parsons WH, Greenlee WJ, Patchett AA. Weber AE, et al. Among authors: parsons wh. J Med Chem. 1991 Sep;34(9):2692-701. doi: 10.1021/jm00113a005. J Med Chem. 1991. PMID: 1895289

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