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Genome-wide association study identifies a single major locus contributing to survival into old age; the APOE locus revisited.
Deelen J, Beekman M, Uh HW, Helmer Q, Kuningas M, Christiansen L, Kremer D, van der Breggen R, Suchiman HE, Lakenberg N, van den Akker EB, Passtoors WM, Tiemeier H, van Heemst D, de Craen AJ, Rivadeneira F, de Geus EJ, Perola M, van der Ouderaa FJ, Gunn DA, Boomsma DI, Uitterlinden AG, Christensen K, van Duijn CM, Heijmans BT, Houwing-Duistermaat JJ, Westendorp RG, Slagboom PE. Deelen J, et al. Among authors: passtoors wm. Aging Cell. 2011 Aug;10(4):686-98. doi: 10.1111/j.1474-9726.2011.00705.x. Epub 2011 May 6. Aging Cell. 2011. PMID: 21418511 Free PMC article.
Gene expression analysis of mTOR pathway: association with human longevity.
Passtoors WM, Beekman M, Deelen J, van der Breggen R, Maier AB, Guigas B, Derhovanessian E, van Heemst D, de Craen AJ, Gunn DA, Pawelec G, Slagboom PE. Passtoors WM, et al. Aging Cell. 2013 Feb;12(1):24-31. doi: 10.1111/acel.12015. Epub 2012 Nov 23. Aging Cell. 2013. PMID: 23061800 Free article.
Meta-analysis on blood transcriptomic studies identifies consistently coexpressed protein-protein interaction modules as robust markers of human aging.
van den Akker EB, Passtoors WM, Jansen R, van Zwet EW, Goeman JJ, Hulsman M, Emilsson V, Perola M, Willemsen G, Penninx BW, Heijmans BT, Maier AB, Boomsma DI, Kok JN, Slagboom PE, Reinders MJ, Beekman M. van den Akker EB, et al. Among authors: passtoors wm. Aging Cell. 2014 Apr;13(2):216-25. doi: 10.1111/acel.12160. Epub 2013 Nov 19. Aging Cell. 2014. PMID: 24119000 Free PMC article.
Transcriptional profiling of human familial longevity indicates a role for ASF1A and IL7R.
Passtoors WM, Boer JM, Goeman JJ, Akker EB, Deelen J, Zwaan BJ, Scarborough A, Breggen Rv, Vossen RH, Houwing-Duistermaat JJ, Ommen GJ, Westendorp RG, van Heemst D, de Craen AJ, White AJ, Gunn DA, Beekman M, Slagboom PE. Passtoors WM, et al. PLoS One. 2012;7(1):e27759. doi: 10.1371/journal.pone.0027759. Epub 2012 Jan 11. PLoS One. 2012. PMID: 22247756 Free PMC article.
IL7R gene expression network associates with human healthy ageing.
Passtoors WM, van den Akker EB, Deelen J, Maier AB, van der Breggen R, Jansen R, Trompet S, van Heemst D, Derhovanessian E, Pawelec G, van Ommen GJ, Slagboom PE, Beekman M. Passtoors WM, et al. Immun Ageing. 2015 Nov 11;12:21. doi: 10.1186/s12979-015-0048-6. eCollection 2015. Immun Ageing. 2015. PMID: 26566388 Free PMC article.
Genomics of human longevity.
Slagboom PE, Beekman M, Passtoors WM, Deelen J, Vaarhorst AA, Boer JM, van den Akker EB, van Heemst D, de Craen AJ, Maier AB, Rozing M, Mooijaart SP, Heijmans BT, Westendorp RG. Slagboom PE, et al. Among authors: passtoors wm. Philos Trans R Soc Lond B Biol Sci. 2011 Jan 12;366(1561):35-42. doi: 10.1098/rstb.2010.0284. Philos Trans R Soc Lond B Biol Sci. 2011. PMID: 21115528 Free PMC article. Review.