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Structural basis of RasGRP binding to high-affinity PKC ligands.
Rong SB, Enyedy IJ, Qiao L, Zhao L, Ma D, Pearce LL, Lorenzo PS, Stone JC, Blumberg PM, Wang S, Kozikowski AP. Rong SB, et al. Among authors: pearce ll. J Med Chem. 2002 Feb 14;45(4):853-60. doi: 10.1021/jm010422z. J Med Chem. 2002. PMID: 11831896
Conformationally constrained analogues of diacylglycerol. 18. The incorporation of a hydroxamate moiety into diacylglycerol-lactones reduces lipophilicity and helps discriminate between sn-1 and sn-2 binding modes to protein kinase C (PK-C). Implications for isozyme specificity.
Lee J, Han KC, Kang JH, Pearce LL, Lewin NE, Yan S, Benzaria S, Nicklaus MC, Blumberg PM, Marquez VE. Lee J, et al. Among authors: pearce ll. J Med Chem. 2001 Dec 6;44(25):4309-12. doi: 10.1021/jm0103965. J Med Chem. 2001. PMID: 11728178
A Potential Antidote for Both Azide and Cyanide Poisonings.
Pearce LL, Garrett KK, Bae Y, Frawley KL, Totoni SC, Peterson J. Pearce LL, et al. J Pharmacol Exp Ther. 2024 Jan 17;388(2):596-604. doi: 10.1124/jpet.123.001719. J Pharmacol Exp Ther. 2024. PMID: 38182416
A Comparison of Potential Azide Antidotes in a Mouse Model.
Frawley KL, Carpenter Totoni S, Bae Y, Pearce LL, Peterson J. Frawley KL, et al. Among authors: pearce ll. Chem Res Toxicol. 2020 Feb 17;33(2):594-603. doi: 10.1021/acs.chemrestox.9b00422. Epub 2020 Jan 23. Chem Res Toxicol. 2020. PMID: 31922405
A Cobalt Schiff-Base Complex as a Putative Therapeutic for Azide Poisoning.
Praekunatham H, Garrett KK, Bae Y, Cronican AA, Frawley KL, Pearce LL, Peterson J. Praekunatham H, et al. Among authors: pearce ll. Chem Res Toxicol. 2020 Feb 17;33(2):333-342. doi: 10.1021/acs.chemrestox.9b00229. Epub 2020 Jan 13. Chem Res Toxicol. 2020. PMID: 31599574
53 results