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Aging phenotype(s) in kidneys of diabetic mice are p66ShcA dependent.
Vashistha H, Marrero L, Reiss K, Cohen AJ, Malhotra A, Javed T, Bradley A, Abbruscato F, Giusti S, Jimenez A, Mehra S, Kaushal D, Giorgio M, Pelicci PG, Kakoki M, Singhal PC, Bunnell B, Meggs LG. Vashistha H, et al. Among authors: pelicci pg. Am J Physiol Renal Physiol. 2018 Dec 1;315(6):F1833-F1842. doi: 10.1152/ajprenal.00608.2017. Epub 2018 Sep 12. Am J Physiol Renal Physiol. 2018. PMID: 30207172 Free PMC article.
A p53-p66Shc signalling pathway controls intracellular redox status, levels of oxidation-damaged DNA and oxidative stress-induced apoptosis.
Trinei M, Giorgio M, Cicalese A, Barozzi S, Ventura A, Migliaccio E, Milia E, Padura IM, Raker VA, Maccarana M, Petronilli V, Minucci S, Bernardi P, Lanfrancone L, Pelicci PG. Trinei M, et al. Among authors: pelicci pg. Oncogene. 2002 May 30;21(24):3872-8. doi: 10.1038/sj.onc.1205513. Oncogene. 2002. PMID: 12032825
Deletion of the p66Shc longevity gene reduces systemic and tissue oxidative stress, vascular cell apoptosis, and early atherogenesis in mice fed a high-fat diet.
Napoli C, Martin-Padura I, de Nigris F, Giorgio M, Mansueto G, Somma P, Condorelli M, Sica G, De Rosa G, Pelicci P. Napoli C, et al. Proc Natl Acad Sci U S A. 2003 Feb 18;100(4):2112-6. doi: 10.1073/pnas.0336359100. Epub 2003 Feb 5. Proc Natl Acad Sci U S A. 2003. PMID: 12571362 Free PMC article.
p66ShcA modulates tissue response to hindlimb ischemia.
Zaccagnini G, Martelli F, Fasanaro P, Magenta A, Gaetano C, Di Carlo A, Biglioli P, Giorgio M, Martin-Padura I, Pelicci PG, Capogrossi MC. Zaccagnini G, et al. Among authors: pelicci pg. Circulation. 2004 Jun 15;109(23):2917-23. doi: 10.1161/01.CIR.0000129309.58874.0F. Epub 2004 Jun 1. Circulation. 2004. PMID: 15173034
Apoptosis and aging: role of p66Shc redox protein.
Migliaccio E, Giorgio M, Pelicci PG. Migliaccio E, et al. Among authors: pelicci pg. Antioxid Redox Signal. 2006 Mar-Apr;8(3-4):600-8. doi: 10.1089/ars.2006.8.600. Antioxid Redox Signal. 2006. PMID: 16677103 Review.
Diabetes promotes cardiac stem cell aging and heart failure, which are prevented by deletion of the p66shc gene.
Rota M, LeCapitaine N, Hosoda T, Boni A, De Angelis A, Padin-Iruegas ME, Esposito G, Vitale S, Urbanek K, Casarsa C, Giorgio M, Lüscher TF, Pelicci PG, Anversa P, Leri A, Kajstura J. Rota M, et al. Among authors: pelicci pg. Circ Res. 2006 Jul 7;99(1):42-52. doi: 10.1161/01.RES.0000231289.63468.08. Epub 2006 Jun 8. Circ Res. 2006. PMID: 16763167
541 results