Pennington MW - Search Results

1

The caspase-like sites of proteasomes, their substrate specificity, new inhibitors and substrates, and allosteric interactions with the trypsin-like sites.

Kisselev AF, Garcia-Calvo M, Overkleeft HS, Peterson E, Pennington MW, Ploegh HL, Thornberry NA, Goldberg AL. Kisselev AF, et al. Among authors: pennington mw. J Biol Chem. 2003 Sep 19;278(38):35869-77. doi: 10.1074/jbc.M303725200. Epub 2003 Jun 18. J Biol Chem. 2003. PMID: 12815064 Free article.

2

Synthesis of a fluorogenic interleukin-1 beta converting enzyme substrate based on resonance energy transfer.

Pennington MW, Thornberry NA. Pennington MW, et al. Pept Res. 1994 Mar-Apr;7(2):72-6. Pept Res. 1994. PMID: 8012123

3

The D-diastereomer of ShK toxin selectively blocks voltage-gated K+ channels and inhibits T lymphocyte proliferation.

Beeton C, Smith BJ, Sabo JK, Crossley G, Nugent D, Khaytin I, Chi V, Chandy KG, Pennington MW, Norton RS. Beeton C, et al. Among authors: pennington mw. J Biol Chem. 2008 Jan 11;283(2):988-97. doi: 10.1074/jbc.M706008200. Epub 2007 Nov 5. J Biol Chem. 2008. PMID: 17984097 Free article.

4

Structure-guided transformation of charybdotoxin yields an analog that selectively targets Ca(2+)-activated over voltage-gated K(+) channels.

Rauer H, Lanigan MD, Pennington MW, Aiyar J, Ghanshani S, Cahalan MD, Norton RS, Chandy KG. Rauer H, et al. Among authors: pennington mw. J Biol Chem. 2000 Jan 14;275(2):1201-8. doi: 10.1074/jbc.275.2.1201. J Biol Chem. 2000. PMID: 10625664 Free article.

5

A novel fluorescent toxin to detect and investigate Kv1.3 channel up-regulation in chronically activated T lymphocytes.

Beeton C, Wulff H, Singh S, Botsko S, Crossley G, Gutman GA, Cahalan MD, Pennington M, Chandy KG. Beeton C, et al. J Biol Chem. 2003 Mar 14;278(11):9928-37. doi: 10.1074/jbc.M212868200. Epub 2003 Jan 2. J Biol Chem. 2003. PMID: 12511563 Free article.

6

Structural conservation of the pores of calcium-activated and voltage-gated potassium channels determined by a sea anemone toxin.

Rauer H, Pennington M, Cahalan M, Chandy KG. Rauer H, et al. J Biol Chem. 1999 Jul 30;274(31):21885-92. doi: 10.1074/jbc.274.31.21885. J Biol Chem. 1999. PMID: 10419508 Free article.

7

Rational design and synthesis of selective BACE-1 inhibitors.

Brady SF, Singh S, Crouthamel MC, Holloway MK, Coburn CA, Garsky VM, Bogusky M, Pennington MW, Vacca JP, Hazuda D, Lai MT. Brady SF, et al. Among authors: pennington mw. Bioorg Med Chem Lett. 2004 Feb 9;14(3):601-4. doi: 10.1016/j.bmcl.2003.11.061. Bioorg Med Chem Lett. 2004. PMID: 14741251

8

ShK-Dap22, a potent Kv1.3-specific immunosuppressive polypeptide.

Kalman K, Pennington MW, Lanigan MD, Nguyen A, Rauer H, Mahnir V, Paschetto K, Kem WR, Grissmer S, Gutman GA, Christian EP, Cahalan MD, Norton RS, Chandy KG. Kalman K, et al. Among authors: pennington mw. J Biol Chem. 1998 Dec 4;273(49):32697-707. doi: 10.1074/jbc.273.49.32697. J Biol Chem. 1998. PMID: 9830012 Free article.

9

Bass hepcidin synthesis, solution structure, antimicrobial activities and synergism, and in vivo hepatic response to bacterial infections.

Lauth X, Babon JJ, Stannard JA, Singh S, Nizet V, Carlberg JM, Ostland VE, Pennington MW, Norton RS, Westerman ME. Lauth X, et al. Among authors: pennington mw. J Biol Chem. 2005 Mar 11;280(10):9272-82. doi: 10.1074/jbc.M411154200. Epub 2004 Nov 16. J Biol Chem. 2005. PMID: 15546886 Free article.

10

A continuous fluorescence-based assay of human cytomegalovirus protease using a peptide substrate.

Holskin BP, Bukhtiyarova M, Dunn BM, Baur P, de Chastonay J, Pennington MW. Holskin BP, et al. Among authors: pennington mw. Anal Biochem. 1995 May 1;227(1):148-55. doi: 10.1006/abio.1995.1264. Anal Biochem. 1995. PMID: 7668375

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