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Preclinical Pharmacology and Pharmacokinetics of Inhaled Hexadecyl-Treprostinil (C16TR), a Pulmonary Vasodilator Prodrug.
Corboz MR, Li Z, Malinin V, Plaunt AJ, Konicek DM, Leifer FG, Chen KJ, Laurent CE, Yin H, Biernat MC, Salvail D, Zhuang J, Xu F, Curran A, Perkins WR, Chapman RW. Corboz MR, et al. Among authors: perkins wr. J Pharmacol Exp Ther. 2017 Dec;363(3):348-357. doi: 10.1124/jpet.117.242099. Epub 2017 Sep 13. J Pharmacol Exp Ther. 2017. PMID: 28904003
Inhaled hexadecyl-treprostinil provides pulmonary vasodilator activity at significantly lower plasma concentrations than infused treprostinil.
Chapman RW, Li Z, Corboz MR, Gauani H, Plaunt AJ, Konicek DM, Leifer FG, Laurent CE, Yin H, Salvail D, Dziak C, Perkins WR, Malinin V. Chapman RW, et al. Among authors: perkins wr. Pulm Pharmacol Ther. 2018 Apr;49:104-111. doi: 10.1016/j.pupt.2018.02.002. Epub 2018 Feb 5. Pulm Pharmacol Ther. 2018. PMID: 29421665 Free article.
Prostanoid receptor subtypes involved in treprostinil-mediated vasodilation of rat pulmonary arteries and in treprostinil-mediated inhibition of collagen gene expression of human lung fibroblasts.
Corboz MR, Salvail W, Gagnon S, LaSala D, Laurent CE, Salvail D, Chen KJ, Cipolla D, Perkins WR, Chapman RW. Corboz MR, et al. Among authors: perkins wr. Prostaglandins Other Lipid Mediat. 2021 Feb;152:106486. doi: 10.1016/j.prostaglandins.2020.106486. Epub 2020 Oct 1. Prostaglandins Other Lipid Mediat. 2021. PMID: 33011365 Free article.
An overview of the biology of a long-acting inhaled treprostinil prodrug.
Chapman RW, Corboz MR, Malinin VS, Plaunt AJ, Konicek DM, Li Z, Perkins WR. Chapman RW, et al. Among authors: perkins wr. Pulm Pharmacol Ther. 2020 Dec;65:102002. doi: 10.1016/j.pupt.2021.102002. Epub 2021 Feb 15. Pulm Pharmacol Ther. 2020. PMID: 33596473 Free article. Review.
51 results