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A randomized study on pharmacodynamic effects of vaginal rings delivering the progesterone receptor modulator ulipristal acetate: research for a novel estrogen-free, method of contraception.
Huang Y, Jensen JT, Brache V, Cochon L, Williams A, Miranda MJ, Croxatto H, Kumar N, Sussman H, Hoskin E, Plagianos M, Roberts K, Merkatz R, Blithe D, Sitruk-Ware R. Huang Y, et al. Among authors: plagianos m. Contraception. 2014 Dec;90(6):565-74. doi: 10.1016/j.contraception.2014.08.006. Epub 2014 Aug 12. Contraception. 2014. PMID: 25193534 Free PMC article. Clinical Trial.
First-in-Human Trial of MIV-150 and Zinc Acetate Coformulated in a Carrageenan Gel: Safety, Pharmacokinetics, Acceptability, Adherence, and Pharmacodynamics.
Friedland BA, Hoesley CJ, Plagianos M, Hoskin E, Zhang S, Teleshova N, Alami M, Novak L, Kleinbeck KR, Katzen LL, Zydowsky TM, Fernández-Romero JA, Creasy GW. Friedland BA, et al. Among authors: plagianos m. J Acquir Immune Defic Syndr. 2016 Dec 15;73(5):489-496. doi: 10.1097/QAI.0000000000001136. J Acquir Immune Defic Syndr. 2016. PMID: 27437826 Free PMC article. Clinical Trial.
Effects of concurrent vaginal miconazole treatment on the absorption and exposure of Nestorone® (segesterone acetate) and ethinyl estradiol delivered from a contraceptive vaginal ring: a randomized, crossover drug-drug interaction study.
Simmons KB, Kumar N, Plagianos M, Roberts K, Hoskin E, Han L, Alami M, Creasy G, Variano B, Merkatz R. Simmons KB, et al. Among authors: plagianos m. Contraception. 2018 Mar;97(3):270-276. doi: 10.1016/j.contraception.2017.10.010. Epub 2017 Oct 31. Contraception. 2018. PMID: 29097225 Clinical Trial.
Segesterone acetate/ethinyl estradiol 12-month contraceptive vaginal system safety evaluation.
Gemzell-Danielsson K, Sitruk-Ware R, Creinin MD, Thomas M, Barnhart KT, Creasy G, Sussman H, Alami M, Burke AE, Weisberg E, Fraser I, Miranda MJ, Gilliam M, Liu J, Carr BR, Plagianos M, Roberts K, Blithe D. Gemzell-Danielsson K, et al. Among authors: plagianos m. Contraception. 2019 Jun;99(6):323-328. doi: 10.1016/j.contraception.2019.02.001. Epub 2019 Mar 1. Contraception. 2019. PMID: 30831102 Free PMC article. Clinical Trial.
Efficacy of the 1-year (13-cycle) segesterone acetate and ethinylestradiol contraceptive vaginal system: results of two multicentre, open-label, single-arm, phase 3 trials.
Archer DF, Merkatz RB, Bahamondes L, Westhoff CL, Darney P, Apter D, Jensen JT, Brache V, Nelson AL, Banks E, Bártfai G, Portman DJ, Plagianos M, Dart C, Kumar N, Creasy GW, Sitruk-Ware R, Blithe DL. Archer DF, et al. Among authors: plagianos m. Lancet Glob Health. 2019 Aug;7(8):e1054-e1064. doi: 10.1016/S2214-109X(19)30265-7. Epub 2019 Jun 20. Lancet Glob Health. 2019. PMID: 31231065 Free PMC article.
Bleeding profile associated with 1-year use of the segesterone acetate/ethinyl estradiol contraceptive vaginal system: pooled analysis from Phase 3 trials.
Vieira CS, Fraser IS, Plagianos MG, Burke AE, Westhoff CL, Jensen J, Brache V, Bahamondes L, Merkatz R, Sitruk-Ware R, Blithe DL. Vieira CS, et al. Contraception. 2019 Dec;100(6):438-444. doi: 10.1016/j.contraception.2019.07.145. Epub 2019 Aug 6. Contraception. 2019. PMID: 31398307 Free PMC article. Clinical Trial.
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