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Preclinical Pharmacology and Pharmacokinetics of Inhaled Hexadecyl-Treprostinil (C16TR), a Pulmonary Vasodilator Prodrug.
Corboz MR, Li Z, Malinin V, Plaunt AJ, Konicek DM, Leifer FG, Chen KJ, Laurent CE, Yin H, Biernat MC, Salvail D, Zhuang J, Xu F, Curran A, Perkins WR, Chapman RW. Corboz MR, et al. Among authors: plaunt aj. J Pharmacol Exp Ther. 2017 Dec;363(3):348-357. doi: 10.1124/jpet.117.242099. Epub 2017 Sep 13. J Pharmacol Exp Ther. 2017. PMID: 28904003
Inhaled hexadecyl-treprostinil provides pulmonary vasodilator activity at significantly lower plasma concentrations than infused treprostinil.
Chapman RW, Li Z, Corboz MR, Gauani H, Plaunt AJ, Konicek DM, Leifer FG, Laurent CE, Yin H, Salvail D, Dziak C, Perkins WR, Malinin V. Chapman RW, et al. Among authors: plaunt aj. Pulm Pharmacol Ther. 2018 Apr;49:104-111. doi: 10.1016/j.pupt.2018.02.002. Epub 2018 Feb 5. Pulm Pharmacol Ther. 2018. PMID: 29421665 Free article.
An overview of the biology of a long-acting inhaled treprostinil prodrug.
Chapman RW, Corboz MR, Malinin VS, Plaunt AJ, Konicek DM, Li Z, Perkins WR. Chapman RW, et al. Among authors: plaunt aj. Pulm Pharmacol Ther. 2020 Dec;65:102002. doi: 10.1016/j.pupt.2021.102002. Epub 2021 Feb 15. Pulm Pharmacol Ther. 2020. PMID: 33596473 Free article. Review.
Characterisation of cough evoked by inhaled treprostinil and treprostinil palmitil.
Chapman RW, Corboz MR, Fernandez C, Sullivan E, Stautberg A, Plaunt AJ, Konicek DM, Malinin V, Li Z, Cipolla D, Perkins W. Chapman RW, et al. Among authors: plaunt aj. ERJ Open Res. 2021 Feb 15;7(1):00592-2020. doi: 10.1183/23120541.00592-2020. eCollection 2021 Jan. ERJ Open Res. 2021. PMID: 33614774 Free PMC article.
Development and Preclinical Evaluation of New Inhaled Lipoglycopeptides for the Treatment of Persistent Pulmonary Methicillin-Resistant Staphylococcus aureus Infections.
Plaunt AJ, Rose SJ, Kang JY, Chen KJ, LaSala D, Heckler RP, Dorfman A, Smith BT, Chun D, Viramontes V, Macaluso A, Li Z, Zhou Y, Mark L, Basso J, Leifer FG, Corboz MR, Chapman RW, Cipolla D, Perkins WR, Malinin VS, Konicek DM. Plaunt AJ, et al. Antimicrob Agents Chemother. 2021 Jun 17;65(7):e0031621. doi: 10.1128/AAC.00316-21. Epub 2021 Jun 17. Antimicrob Agents Chemother. 2021. PMID: 33941518 Free PMC article.
Recent advances in prodrug-based nanoparticle therapeutics.
Chen KJ, Plaunt AJ, Leifer FG, Kang JY, Cipolla D. Chen KJ, et al. Among authors: plaunt aj. Eur J Pharm Biopharm. 2021 Aug;165:219-243. doi: 10.1016/j.ejpb.2021.04.025. Epub 2021 May 9. Eur J Pharm Biopharm. 2021. PMID: 33979661 Free article. Review.
20 results