Ploegh HL - Search Results

1

The caspase-like sites of proteasomes, their substrate specificity, new inhibitors and substrates, and allosteric interactions with the trypsin-like sites.

Kisselev AF, Garcia-Calvo M, Overkleeft HS, Peterson E, Pennington MW, Ploegh HL, Thornberry NA, Goldberg AL. Kisselev AF, et al. Among authors: ploegh hl. J Biol Chem. 2003 Sep 19;278(38):35869-77. doi: 10.1074/jbc.M303725200. Epub 2003 Jun 18. J Biol Chem. 2003. PMID: 12815064 Free article.

2

Pathways accessory to proteasomal proteolysis are less efficient in major histocompatibility complex class I antigen production.

Kessler B, Hong X, Petrovic J, Borodovsky A, Dantuma NP, Bogyo M, Overkleeft HS, Ploegh H, Glas R. Kessler B, et al. J Biol Chem. 2003 Mar 21;278(12):10013-21. doi: 10.1074/jbc.M211221200. Epub 2002 Dec 16. J Biol Chem. 2003. PMID: 12488316 Free article.

3

Extended peptide-based inhibitors efficiently target the proteasome and reveal overlapping specificities of the catalytic beta-subunits.

Kessler BM, Tortorella D, Altun M, Kisselev AF, Fiebiger E, Hekking BG, Ploegh HL, Overkleeft HS. Kessler BM, et al. Among authors: ploegh hl. Chem Biol. 2001 Sep;8(9):913-29. doi: 10.1016/s1074-5521(01)00069-2. Chem Biol. 2001. PMID: 11564559

4

Chemistry in living cells: detection of active proteasomes by a two-step labeling strategy.

Ovaa H, van Swieten PF, Kessler BM, Leeuwenburgh MA, Fiebiger E, van den Nieuwendijk AM, Galardy PJ, van der Marel GA, Ploegh HL, Overkleeft HS. Ovaa H, et al. Among authors: ploegh hl. Angew Chem Int Ed Engl. 2003 Aug 11;42(31):3626-9. doi: 10.1002/anie.200351314. Angew Chem Int Ed Engl. 2003. PMID: 12916032 No abstract available.

5

A novel active site-directed probe specific for deubiquitylating enzymes reveals proteasome association of USP14.

Borodovsky A, Kessler BM, Casagrande R, Overkleeft HS, Wilkinson KD, Ploegh HL. Borodovsky A, et al. Among authors: ploegh hl. EMBO J. 2001 Sep 17;20(18):5187-96. doi: 10.1093/emboj/20.18.5187. EMBO J. 2001. PMID: 11566882 Free PMC article.

6

Covalent modification of the active site threonine of proteasomal beta subunits and the Escherichia coli homolog HslV by a new class of inhibitors.

Bogyo M, McMaster JS, Gaczynska M, Tortorella D, Goldberg AL, Ploegh H. Bogyo M, et al. Proc Natl Acad Sci U S A. 1997 Jun 24;94(13):6629-34. doi: 10.1073/pnas.94.13.6629. Proc Natl Acad Sci U S A. 1997. PMID: 9192616 Free PMC article.

7

Structure of the ubiquitin hydrolase UCH-L3 complexed with a suicide substrate.

Misaghi S, Galardy PJ, Meester WJ, Ovaa H, Ploegh HL, Gaudet R. Misaghi S, et al. Among authors: ploegh hl. J Biol Chem. 2005 Jan 14;280(2):1512-20. doi: 10.1074/jbc.M410770200. Epub 2004 Nov 5. J Biol Chem. 2005. PMID: 15531586 Free article.

8

Analysis of protease activity in live antigen-presenting cells shows regulation of the phagosomal proteolytic contents during dendritic cell activation.

Lennon-Duménil AM, Bakker AH, Maehr R, Fiebiger E, Overkleeft HS, Rosemblatt M, Ploegh HL, Lagaudrière-Gesbert C. Lennon-Duménil AM, et al. Among authors: ploegh hl. J Exp Med. 2002 Aug 19;196(4):529-40. doi: 10.1084/jem.20020327. J Exp Med. 2002. PMID: 12186844 Free PMC article.

9

Functional proteomics of the active cysteine protease content in Drosophila S2 cells.

Kocks C, Maehr R, Overkleeft HS, Wang EW, Iyer LK, Lennon-Dumenil AM, Ploegh HL, Kessler BM. Kocks C, et al. Among authors: ploegh hl. Mol Cell Proteomics. 2003 Nov;2(11):1188-97. doi: 10.1074/mcp.M300067-MCP200. Epub 2003 Sep 16. Mol Cell Proteomics. 2003. PMID: 13130081 Free article.

10

The p41 isoform of invariant chain is a chaperone for cathepsin L.

Lennon-Duménil AM, Roberts RA, Valentijn K, Driessen C, Overkleeft HS, Erickson A, Peters PJ, Bikoff E, Ploegh HL, Wolf Bryant P. Lennon-Duménil AM, et al. Among authors: ploegh hl. EMBO J. 2001 Aug 1;20(15):4055-64. doi: 10.1093/emboj/20.15.4055. EMBO J. 2001. PMID: 11483509 Free PMC article.

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