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Pharmacological suppression of hepcidin increases macrophage cholesterol efflux and reduces foam cell formation and atherosclerosis.
Saeed O, Otsuka F, Polavarapu R, Karmali V, Weiss D, Davis T, Rostad B, Pachura K, Adams L, Elliott J, Taylor WR, Narula J, Kolodgie F, Virmani R, Hong CC, Finn AV. Saeed O, et al. Among authors: polavarapu r. Arterioscler Thromb Vasc Biol. 2012 Feb;32(2):299-307. doi: 10.1161/ATVBAHA.111.240101. Epub 2011 Nov 17. Arterioscler Thromb Vasc Biol. 2012. PMID: 22095982 Free PMC article.
Metformin impairs vascular endothelial recovery after stent placement in the setting of locally eluted mammalian target of rapamycin inhibitors via S6 kinase-dependent inhibition of cell proliferation.
Habib A, Karmali V, Polavarapu R, Akahori H, Nakano M, Yazdani S, Otsuka F, Pachura K, Davis T, Narula J, Kolodgie FD, Virmani R, Finn AV. Habib A, et al. Among authors: polavarapu r. J Am Coll Cardiol. 2013 Mar 5;61(9):971-80. doi: 10.1016/j.jacc.2012.12.018. J Am Coll Cardiol. 2013. PMID: 23449430 Free PMC article.
Hepcidin-ferroportin axis controls toll-like receptor 4 dependent macrophage inflammatory responses in human atherosclerotic plaques.
Habib A, Polavarapu R, Karmali V, Guo L, Van Dam R, Cheng Q, Akahori H, Saeed O, Nakano M, Pachura K, Hong CC, Shin E, Kolodgie F, Virmani R, Finn AV. Habib A, et al. Among authors: polavarapu r. Atherosclerosis. 2015 Aug;241(2):692-700. doi: 10.1016/j.atherosclerosis.2015.06.025. Epub 2015 Jun 19. Atherosclerosis. 2015. PMID: 26125411 Free PMC article.
Differential healing after sirolimus, paclitaxel, and bare metal stent placement in combination with peroxisome proliferator-activator receptor gamma agonists: requirement for mTOR/Akt2 in PPARgamma activation.
Finn AV, John M, Nakazawa G, Polavarapu R, Karmali V, Xu X, Cheng Q, Davis T, Raghunathan C, Acampado E, Ezell T, Lajoie S, Eppihimer M, Kolodgie FD, Virmani R, Gold HK. Finn AV, et al. Among authors: polavarapu r. Circ Res. 2009 Nov 6;105(10):1003-12. doi: 10.1161/CIRCRESAHA.109.200519. Epub 2009 Sep 24. Circ Res. 2009. PMID: 19797172 Free PMC article.
Sirolimus-FKBP12.6 impairs endothelial barrier function through protein kinase C-α activation and disruption of the p120-vascular endothelial cadherin interaction.
Habib A, Karmali V, Polavarapu R, Akahori H, Cheng Q, Pachura K, Kolodgie FD, Finn AV. Habib A, et al. Among authors: polavarapu r. Arterioscler Thromb Vasc Biol. 2013 Oct;33(10):2425-31. doi: 10.1161/ATVBAHA.113.301659. Epub 2013 Jul 25. Arterioscler Thromb Vasc Biol. 2013. PMID: 23887639 Free PMC article.
Everolimus-eluting stents improve vascular response in a diabetic animal model.
Habib A, Karmali V, John MC, Polavarapu R, Nakazawa G, Pachura K, Davis T, Kolodgie FD, Virmani R, Finn AV. Habib A, et al. Among authors: polavarapu r. Circ Cardiovasc Interv. 2014 Aug;7(4):526-32. doi: 10.1161/CIRCINTERVENTIONS.113.001023. Epub 2014 Jun 10. Circ Cardiovasc Interv. 2014. PMID: 24915972 Free PMC article.
CD163 interacts with TWEAK to regulate tissue regeneration after ischaemic injury.
Akahori H, Karmali V, Polavarapu R, Lyle AN, Weiss D, Shin E, Husain A, Naqvi N, Van Dam R, Habib A, Choi CU, King AL, Pachura K, Taylor WR, Lefer DJ, Finn AV. Akahori H, et al. Among authors: polavarapu r. Nat Commun. 2015 Aug 5;6:7792. doi: 10.1038/ncomms8792. Nat Commun. 2015. PMID: 26242746 Free PMC article.
CD163+ macrophages promote angiogenesis and vascular permeability accompanied by inflammation in atherosclerosis.
Guo L, Akahori H, Harari E, Smith SL, Polavarapu R, Karmali V, Otsuka F, Gannon RL, Braumann RE, Dickinson MH, Gupta A, Jenkins AL, Lipinski MJ, Kim J, Chhour P, de Vries PS, Jinnouchi H, Kutys R, Mori H, Kutyna MD, Torii S, Sakamoto A, Choi CU, Cheng Q, Grove ML, Sawan MA, Zhang Y, Cao Y, Kolodgie FD, Cormode DP, Arking DE, Boerwinkle E, Morrison AC, Erdmann J, Sotoodehnia N, Virmani R, Finn AV. Guo L, et al. Among authors: polavarapu r. J Clin Invest. 2018 Mar 1;128(3):1106-1124. doi: 10.1172/JCI93025. Epub 2018 Feb 19. J Clin Invest. 2018. PMID: 29457790 Free PMC article.
66 results