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Negative regulators of integrin activity.
Pouwels J, Nevo J, Pellinen T, Ylänne J, Ivaska J. Pouwels J, et al. J Cell Sci. 2012 Jul 15;125(Pt 14):3271-80. doi: 10.1242/jcs.093641. Epub 2012 Jul 20. J Cell Sci. 2012. PMID: 22822081
SHANK proteins limit integrin activation by directly interacting with Rap1 and R-Ras.
Lilja J, Zacharchenko T, Georgiadou M, Jacquemet G, De Franceschi N, Peuhu E, Hamidi H, Pouwels J, Martens V, Nia FH, Beifuss M, Boeckers T, Kreienkamp HJ, Barsukov IL, Ivaska J. Lilja J, et al. Among authors: pouwels j. Nat Cell Biol. 2017 Apr;19(4):292-305. doi: 10.1038/ncb3487. Epub 2017 Mar 6. Nat Cell Biol. 2017. PMID: 28263956 Free PMC article.
SHARPIN is an endogenous inhibitor of β1-integrin activation.
Rantala JK, Pouwels J, Pellinen T, Veltel S, Laasola P, Mattila E, Potter CS, Duffy T, Sundberg JP, Kallioniemi O, Askari JA, Humphries MJ, Parsons M, Salmi M, Ivaska J. Rantala JK, et al. Among authors: pouwels j. Nat Cell Biol. 2011 Sep 25;13(11):1315-24. doi: 10.1038/ncb2340. Nat Cell Biol. 2011. PMID: 21947080 Free PMC article.
SHARPIN regulates uropod detachment in migrating lymphocytes.
Pouwels J, De Franceschi N, Rantakari P, Auvinen K, Karikoski M, Mattila E, Potter C, Sundberg JP, Hogg N, Gahmberg CG, Salmi M, Ivaska J. Pouwels J, et al. Cell Rep. 2013 Nov 14;5(3):619-28. doi: 10.1016/j.celrep.2013.10.011. Epub 2013 Nov 7. Cell Rep. 2013. PMID: 24210817 Free PMC article.
60 results