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MT5-MMP is a new pro-amyloidogenic proteinase that promotes amyloid pathology and cognitive decline in a transgenic mouse model of Alzheimer's disease.
Cell Mol Life Sci. 2016 Jan;73(1):217-36. doi: 10.1007/s00018-015-1992-1. Epub 2015 Jul 23.
Cell Mol Life Sci. 2016.
PMID: 26202697
Free PMC article.
Differential spatio-temporal regulation of MMPs in the 5xFAD mouse model of Alzheimer's disease: evidence for a pro-amyloidogenic role of MT1-MMP.
Py NA, Bonnet AE, Bernard A, Marchalant Y, Charrat E, Checler F, Khrestchatisky M, Baranger K, Rivera S.
Py NA, et al.
Front Aging Neurosci. 2014 Sep 18;6:247. doi: 10.3389/fnagi.2014.00247. eCollection 2014.
Front Aging Neurosci. 2014.
PMID: 25278878
Free PMC article.
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Proamyloidogenic effects of membrane type 1 matrix metalloproteinase involve MMP-2 and BACE-1 activities, and the modulation of APP trafficking.
Paumier JM, Py NA, García-González L, Bernard A, Stephan D, Louis L, Checler F, Khrestchatisky M, Baranger K, Rivera S.
Paumier JM, et al. Among authors: py na.
FASEB J. 2019 Feb;33(2):2910-2927. doi: 10.1096/fj.201801076R. Epub 2018 Oct 17.
FASEB J. 2019.
PMID: 30332299
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